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    Spn43Ab Serpin 43Ab [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn43Abprovided by FlyBase
    Official Full Name
    Serpin 43Abprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024293
    Locus tag
    Dmel_CG1865
    See related
    AllianceGenome:FB:FBgn0024293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118057.2; CG1865; Dmel\CG1865; Ser2; SER2; spn43Ab
    Summary
    Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); retinal vascular disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn43Ab in Genome Data Viewer
    Location:
    42F3-42F3; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7151662..7153642, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3039167..3041147, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44200 Neighboring gene Serpin 43Aa Neighboring gene uncharacterized protein Neighboring gene Serpin 43Ad Neighboring gene prickle Neighboring gene necrotic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Green C, et al. Genetics, 2000 Nov. PMID 11063688, Free PMC Article
    2. The microevolutionary response to male-limited X-chromosome evolution in Drosophila melanogaster reflects macroevolutionary patterns. Abbott JK, et al. J Evol Biol, 2020 Jun. PMID 32176391
    3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
    4. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Levashina EA, et al. Science, 1999 Sep 17. PMID 10489372
    5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 43Ab
    Names
    CG1865-PB
    Spn43Ab-PB
    serine protease inhibitor 2
    serine protease inhibitor 43Ab

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7151662..7153642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032224.2 → NP_001027395.1  serpin 43Ab [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6V5, Q9U5W8
      Conserved Domains (1) summary
      cd00172
      Location:30 → 387
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6V5 A1Z6V5
    Q9U5W8 Q9U5W8

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