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    jet jetlag [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jetprovided by FlyBase
    Official Full Name
    jetlagprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031652
    Locus tag
    Dmel_CG8873
    See related
    AllianceGenome:FB:FBgn0031652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8873; Dmel\CG8873; FBXL15; Jet; JET; JETLAG
    Summary
    Involved in entrainment of circadian clock by photoperiod and locomotor rhythm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL15 (F-box and leucine rich repeat protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jet in Genome Data Viewer
    Location:
    25B4-25B4; 2-14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4948206..4949784, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4948206..4949784, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Salivary gland secretion 1 Neighboring gene sayonara Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene beta subunit of type I geranylgeranyl transferase Neighboring gene Jonah 25Biii Neighboring gene Jonah 25Bii

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reaction mechanism of Drosophila cryptochrome. Ozturk N, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187431, Free PMC Article
    2. Changes in active site histidine hydrogen bonding trigger cryptochrome activation. Ganguly A, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27551082, Free PMC Article
    3. Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Tang CH, et al. Neuron, 2010 May 13. PMID 20471351, Free PMC Article
    4. Flavin reduction activates Drosophila cryptochrome. Vaidya AT, et al. Proc Natl Acad Sci U S A, 2013 Dec 17. PMID 24297896, Free PMC Article
    5. Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore. Ozturk N, et al. J Biol Chem, 2014 Feb 21. PMID 24379403, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that JET is essential for resetting the circadian clock by transmitting light signals from cryptochrome to TIMELESS [JET]
      Title: JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
    2. show a strong interaction between Veela and cryptochrome genetic variants, demonstrating that the Jetlag, Timeless, and cryptochrome proteins function in the same pathway.
      Title: Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    jetlag
    Names
    CG8873-PA
    CG8873-PB
    jet-PA
    jet-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4948206..4949784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042867.2 → NP_001036332.1  jetlag, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5H0I4, Q0E8T8, Q8T0E8
      Conserved Domains (2) summary
      cd09293
      Location:96 → 280
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:85 → 110
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_135036.3 → NP_608880.2  jetlag, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608880.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5H0I4, Q8T0E8, Q9VMY0
      Related
      FBpp0078693
      Conserved Domains (2) summary
      cd09293
      Location:96 → 261
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:85 → 110
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8T8 Q0E8T8
    Q8T0E8 Q8T0E8
    Q9VMY0 Q9VMY0

    Gene LinkOut

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