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    mr morula [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrprovided by FlyBase
    Official Full Name
    morulaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002791
    Locus tag
    Dmel_CG3060
    See related
    AllianceGenome:FB:FBgn0002791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apc2; APC2; APC2/mr; CG3060; dAPC2; Dmel\CG3060; Mr; MR
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in modulation of chemical synaptic transmission and negative regulation of synaptic assembly at neuromuscular junction. Part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    60A15-60A15; 2-105 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23972431..23975408)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19859954..19862931)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene orange Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 1 regulatory subunit 15 Neighboring gene Sox box protein 14 Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Hainline SG, et al. Biol Open, 2014 Jun 27. PMID 24972868, Free PMC Article
    2. Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A. Liu T, et al. FASEB J, 2017 May. PMID 28188175
    3. Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Sugimura I, et al. Dev Cell, 2006 Jan. PMID 16399084
    4. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Nagy O, et al. Cell Div, 2012 Mar 14. PMID 22417125, Free PMC Article
    5. The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis. Braun AL, et al. Open Biol, 2021 Jun. PMID 34186008, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mr encodes the APC2 subunit of the anaphase promoting complex/cyclosome
      Title: The anaphase promoting complex/cyclosome is required during development for modified cell cycles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    morula
    Names
    CG3060-PA
    mr-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23972431..23975408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138018.3 → NP_611862.1  morula [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1E5
      Related
      FBpp0072065
      Conserved Domains (2) summary
      smart01013
      Location:741 → 800
      APC2; Anaphase promoting complex (APC) subunit 2
      smart00182
      Location:494 → 632
      CULLIN; Cullin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TK2 Q95TK2
    Q9W1E5 Q9W1E5

    Gene LinkOut

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