U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cmpk Cytidine/uridine monophosphate kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43165, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cmpkprovided by FlyBase
    Official Full Name
    Cytidine/uridine monophosphate kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028833
    Locus tag
    Dmel_CG6092
    See related
    AllianceGenome:FB:FBgn0028833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.320; CG6092; dak1; Dak1; Dak1L; Dm.UMP-CMP kinase; Dmel\CG6092; UMP-CMPK
    Summary
    Enables (d)CMP kinase activity and UMP/dUMP kinase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process; CDP biosynthetic process; and UDP biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cmpk in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26054237..26055438, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21879959..21881160, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene groucho Neighboring gene Exocyst 84 Neighboring gene Vacuolar protein sorting 2 Neighboring gene Sld5 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Threonyl-carbamoyl synthesis 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal. Curbo S, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592433
    2. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
    3. Proteomic profiling of thermal acclimation in Drosophila melanogaster. Colinet H, et al. Insect Biochem Mol Biol, 2013 Apr. PMID 23416132
    4. Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins. DeLuca SZ, et al. Elife, 2020 Aug 10. PMID 32773039, Free PMC Article
    5. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (d)CMP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (d)CMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UMP/dUMP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UMP/dUMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in CDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing compound metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cytidine/uridine monophosphate kinase 1
    Names
    CG6092-PA
    Cmpk-PA
    Dak1
    UMP-CMP kinase
    NP_651456.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26054237..26055438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143199.3 → NP_651456.1  Cytidine/uridine monophosphate kinase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGD0, Q9VBI2
      Related
      FBpp0084349
      Conserved Domains (2) summary
      cd01428
      Location:65 → 240
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01359
      Location:65 → 249
      UMP_CMP_kin_fam; UMP-CMP kinase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGD0 Q8IGD0
    Q9TW62 Q9TW62
    Q9VBI2 Q9VBI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous