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    pr purple [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prprovided by FlyBase
    Official Full Name
    purpleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003141
    Locus tag
    Dmel_CG16784
    See related
    AllianceGenome:FB:FBgn0003141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.9; anon-38Bb; CG16784; Dmel\CG16784; PTPS
    Summary
    Predicted to enable 6-pyruvoyltetrahydropterin synthase activity. Involved in pteridine biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    38B3-38B3; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20073719..20075458, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20073719..20075458, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44907 Neighboring gene brain washing Neighboring gene uncharacterized protein Neighboring gene nebbish Neighboring gene fledgling of Klp38B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental changes of sepiapterin synthase activity associated with a variegated purple gene in Drosophila melanogaster. Tobler JE, et al. Biochem Genet, 1979 Feb. PMID 110316
    2. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the synthesis of sepiapterin from dihydroneopterin triphosphate. Krivi GG, et al. Biochem Genet, 1979 Apr. PMID 114165
    3. Mechanism of suppression in Drosophila. V. Localization of the purple mutant of Drosophila melanogaster in the pteridine biosynthetic pathway. Wilson TG, et al. Biochem Genet, 1977 Apr. PMID 405969
    4. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from Drosophila melanogaster. Park YS, et al. Biochim Biophys Acta, 1990 Apr 19. PMID 2110003
    5. Mechanism of suppression in Drosophila: control of sepiapterin synthase at the purple locus. Yim JJ, et al. Science, 1977 Dec 16. PMID 412253

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 6-pyruvoyltetrahydropterin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pteridine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    purple
    Names
    CG16784-PC
    pr-PC
    NP_724244.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20073719..20075458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165319.3 → NP_724244.1  purple [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0X1, P48611, Q9VIP5
      Related
      FBpp0088417
      Conserved Domains (1) summary
      cd00470
      Location:6 → 141
      PTPS; 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48611.1 P48611

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