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    TwdlW TweedleW [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlWprovided by FlyBase
    Official Full Name
    TweedleWprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038487
    Locus tag
    Dmel_CG4060
    See related
    AllianceGenome:FB:FBgn0038487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4060; Dmel\CG4060; twdlW
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlW in Genome Data Viewer
    Location:
    89F1-89F1; 3-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17141208..17142404, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12966930..12968126, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mann-cup Neighboring gene Deterin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MOD(MDG4)-64.2 protein, isoform of MOD(MDG4) loci, directly interacts with the Tweedle protein family of Drosophila melanogaster. Golovnin AK, et al. Dokl Biochem Biophys, 2013 Sep. PMID 24150578
    2. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
    3. The distribution of GYR- and YLP-like motifs in Drosophila suggests a general role in cuticle assembly and other protein-protein interactions. Cornman RS. PLoS One, 2010 Sep 2. PMID 20824096, Free PMC Article
    4. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article
    5. Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle. Cornman RS, et al. Insect Mol Biol, 2009 Oct. PMID 19754739, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleW
    Names
    CG4060-PA
    TwdlW-PA
    tweedle
    tweedle W

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17141208..17142404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142349.3 → NP_650606.2  TweedleW [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650606.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH13, Q9VEM3
      Related
      FBpp0082856
      Conserved Domains (1) summary
      smart00690
      Location:127 → 227
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IH13 Q8IH13

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