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    Mettl2 Methyltransferase like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl2provided by FlyBase
    Official Full Name
    Methyltransferase like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035247
    Locus tag
    Dmel_CG13929
    See related
    AllianceGenome:FB:FBgn0035247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey109; CG13929; Dmel\CG13929; metl; Metl; METTL2A; METTL2B
    Summary
    Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Is expressed in organism. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mettl2 in Genome Data Viewer
    Location:
    62A9-62A9; 3-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1637942..1639235, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1637942..1639235, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin Neighboring gene Coat Protein (coatomer) alpha Neighboring gene Big brother

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. Zhang SX, et al. Gene, 2001 Dec 12. PMID 11738826
    2. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
    3. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA (cytidine) methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase like 2
    Names
    CG13929-PA
    CG13929-PB
    Mettl2-PA
    Mettl2-PB
    methyltransferase-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1637942..1639235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167907.3 → NP_728647.2  methyltransferase like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728647.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB75
      Related
      FBpp0072695
      Conserved Domains (2) summary
      COG0500
      Location:72 → 301
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:115 → 217
      Methyltransf_12; Methyltransferase domain

    2. NM_139379.4 → NP_647636.3  methyltransferase like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647636.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86BS6, Q960S9, Q9W0C0
      Related
      FBpp0072696
      Conserved Domains (2) summary
      COG0500
      Location:95 → 324
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:138 → 240
      Methyltransf_12; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BS6.2 Q86BS6

    Gene LinkOut

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