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    CG1827 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1827provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033431
    Locus tag
    Dmel_CG1827
    See related
    AllianceGenome:FB:FBgn0033431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg1827; Dmel\CG1827
    Summary
    Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be involved in protein deglycosylation. Predicted to be active in lysosome. Is expressed in adult head; adult heart; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1827 in Genome Data Viewer
    Location:
    45F5-45F5; 2-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9589050..9590443)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5476555..5477948)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene closca Neighboring gene Microtubule-associated protein 60 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human BOULE gene rescues meiotic defects in infertile flies. Xu EY, et al. Hum Mol Genet, 2003 Jan 15. PMID 12499397
    2. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article
    3. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
    4. Endogenously imprinted genes in Drosophila melanogaster. McEachern LA, et al. Mol Genet Genomics, 2014 Aug. PMID 24658702
    5. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons. Xie Q, et al. Elife, 2021 Jan 11. PMID 33427646, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deglycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1827-PD
    NP_610504.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9589050..9590443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136660.3 → NP_610504.4  uncharacterized protein Dmel_CG1827 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610504.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7W5, A1Z7W6, Q6NN89, Q8MR45
      Conserved Domains (1) summary
      cd04513
      Location:58 → 366
      Glycosylasparaginase; Glycosylasparaginase and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR45.1 Q8MR45

    Gene LinkOut

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