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    Flad1 Flavin adenine dinucleotide synthetase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flad1provided by FlyBase
    Official Full Name
    Flavin adenine dinucleotide synthetase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030431
    Locus tag
    Dmel_CG4407
    See related
    AllianceGenome:FB:FBgn0030431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4407; Dmel\CG4407; Fad1
    Summary
    Predicted to enable FMN adenylyltransferase activity. Predicted to be involved in FAD biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Flad1 in Genome Data Viewer
    Location:
    11D1-11D1; 1-41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12901353..12903516, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12795386..12797549, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q8 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L49

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila radish gene encodes a protein required for anesthesia-resistant memory. Folkers E, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088531, Free PMC Article
    2. Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. Raza Q, et al. PLoS Genet, 2019 Feb. PMID 30763317, Free PMC Article
    3. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article
    4. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. Ke H, et al. J Genet Genomics, 2018 Jun 1. PMID 29935791
    5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN adenylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in FAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FAD biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    flavin adenine dinucleotide synthetase 1
    Names
    CG4407-PA
    CG4407-PB
    Flad1-PA
    Flad1-PB
    NP_572837.1
    NP_727648.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12901353..12903516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132609.4 → NP_572837.1  flavin adenine dinucleotide synthetase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961A2, Q9VYI5
      Related
      FBpp0073528
      Conserved Domains (1) summary
      cd01713
      Location:118 → 267
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

    2. NM_167342.2 → NP_727648.1  flavin adenine dinucleotide synthetase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR76
      Related
      FBpp0073529
      Conserved Domains (1) summary
      cd01713
      Location:90 → 239
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR76 Q8IR76
    Q9VYI5 Q9VYI5

    Gene LinkOut

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