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    CG2187 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2187provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017448
    Locus tag
    Dmel_CG2187
    See related
    AllianceGenome:FB:FBgn0017448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-100EF-D3; D3-100EF; Dmel\CG2187; dSLC5A6
    Summary
    Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2187 in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31755356..31758637, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27581078..27584359, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene salty dog Neighboring gene mir-1014 stem loop Neighboring gene long non-coding RNA:CR44263 Neighboring gene Sodium-dependent multivitamin transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila. Dus M, et al. Nat Neurosci, 2013 May. PMID 23542692, Free PMC Article
    2. The Female Post-Mating Response Requires Genes Expressed in the Secondary Cells of the Male Accessory Gland in Drosophila melanogaster. Sitnik JL, et al. Genetics, 2016 Mar. PMID 26746709, Free PMC Article
    3. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article
    4. Gene expression profiling of brakeless mutant Drosophila embryos. Crona F, et al. Data Brief, 2015 Dec. PMID 26509186, Free PMC Article
    5. Molecular and comparative genetics of mental retardation. Inlow JK, et al. Genetics, 2004 Feb. PMID 15020472, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2187-PA
    CG2187-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31755356..31758637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143633.2 → NP_651890.1  uncharacterized protein Dmel_CG2187, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91659
      Related
      FBpp0085220
      Conserved Domains (1) summary
      cd11492
      Location:27 → 561
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

    2. NM_001202402.1 → NP_001189331.1  uncharacterized protein Dmel_CG2187, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91659
      Conserved Domains (1) summary
      cd11492
      Location:27 → 561
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91659 P91659

    Gene LinkOut

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