drd drop dead [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: drdprovided by FlyBase
Official Full Name: drop deadprovided by FlyBase
Primary source: FLYBASE:FBgn0260006
Locus tag: Dmel_CG33968
See related: AllianceGenome:FB:FBgn0260006
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM06434; beltless; blt; CG32589; CG33968; CG5652; Dmel\CG33968; GM06434; lwf
Summary: Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Involved in chitin-based cuticle development; digestive system process; and oogenesis. Located in organelle membrane. Is expressed in several structures, including adult brain cell body rind; adult head; epithelium; gland; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13A12-13B1; 1-50 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15125753..15137311)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15019786..15031344)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutants lack peritrophic matrix
Title: Pleiotropic and novel phenotypes in the Drosophila gut caused by mutation of drop-dead.
There are at least two causes of adult lethality in drd mutants; gut dysfunction and neurodegeneration are independent phenotypes, neurodegeneration being associated with respiratory system dysfunction.
Title: Neurodegeneration in drop-dead mutant drosophila melanogaster is associated with the respiratory system but not with Hypoxia.
The adult-lethal gene drd is required only during development. The mutant phenotypes of body mass and lifespan are separable phenotypes arising from an absence of drd expression at different developmental stages.
Title: Developmental expression of drop-dead is required for early adult survival and normal body mass in Drosophila melanogaster.
nonsense mutation causes defects in food processing by the digestive system and in oogenesis
Title: Cloning of the neurodegeneration gene drop-dead and characterization of additional phenotypes of its mutation.
These findings are consistent with the previously reported loss in body control in the mutant and thus demonstrate the significance of the drop-dead gene for running behaviour in Drosophila.
Title: Locomotor performance in the Drosophila brain mutant drop-dead.
Identification of a novel Drosophila gene, beltless, which is expressed in multiple developmental stages and in adult Drosophila.
Title: Identification of a novel Drosophila gene, beltless, using injectable embryonic and adult RNA interference (RNAi).

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: drop dead

Names: CG33968-PA; beltless; drd-PA; drop-dead; lot's wife; lots wife

NP_001033845.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15125753..15137311

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038756.2 → NP_001033845.1 drop dead [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033845.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BII4, Q8IR42

Conserved Domains (3) summary

smart00703
Location:169 → 289

NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)

COG1835
Location:371 → 791

OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]

pfam01757
Location:384 → 770

Acyl_transf_3; Acyltransferase family