CG7544 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG7544provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0033994
Locus tag: Dmel_CG7544
See related: AllianceGenome:FB:FBgn0033994
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG7544; METTL16
Summary: Predicted to enable 23S rRNA (adenine(1618)-N(6))-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51E2-51E2; 2-74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15147860..15149709)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11035365..11037214)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG7544-PA; CG7544-PB

NP_001163156.1

EC 2.1.1.-

EC 2.1.1.181

NP_611015.1

EC 2.1.1.-

EC 2.1.1.181

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15147860..15149709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169685.2 → NP_001163156.1 uncharacterized protein Dmel_CG7544, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163156.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K3B9

UniProtKB/TrEMBL

E1JH71

Conserved Domains (1) summary

cl17173
Location:45 → 295

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_137171.4 → NP_611015.1 uncharacterized protein Dmel_CG7544, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611015.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K3B9

UniProtKB/TrEMBL

E1JH71

Related

FBpp0086548

Conserved Domains (1) summary

cl17173
Location:45 → 295

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...