Ptp61F Protein tyrosine phosphatase 61F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptp61Fprovided by FlyBase
Official Full Name: Protein tyrosine phosphatase 61Fprovided by FlyBase
Primary source: FLYBASE:FBgn0267487
Locus tag: Dmel_CG9181
See related: AllianceGenome:FB:FBgn0267487
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.297; anon-WO0140519.98; BEST:LP01280; CG9178; CG9181; CPtp62A; DCPTP62A; Dmel\CG9181; dptp61F; dPTP61F; DPTP61F; Ptp-61F; PTP1b; PTP1B; ptp61F; Ptp61f; PTP61F; R-PTP 61F
Summary: Enables non-membrane spanning protein tyrosine phosphatase activity and protein sequestering activity. Involved in several processes, including cellular response to mechanical stimulus; germ-band extension; and negative regulation of signal transduction. Located in mitochondrial envelope; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; central brain primordium; male germline cell; and somatic cell of testis. Used to study intestinal cancer. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61F7-62A2; 3-0.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1342493..1475257, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1342493..1475257, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-137 regulates PTP61F, affecting insulin signaling, metabolic homeostasis, and starvation resistance in Drosophila.
Title: miR-137 regulates PTP61F, affecting insulin signaling, metabolic homeostasis, and starvation resistance in Drosophila.
Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size.
Title: Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size.
Examination of the epistatic relationship between candidate genes and Stat92E reveals that Ptp61F and brm interact with Stat92E during both border cell specification and migration.
Title: Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Title: Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.
Modulation of hyperactive MAP kinase activity by Ptp61F alleles, the phosphatase intervenes to directly or indirectly to regulate MAP kinase.
Title: Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B.
The PTP61F variants differ in their capacities to regulate growth.
Title: The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity.
Studies reveal for the first time that the adaptor protein Dock/Nck attenuates insulin signalling by recruiting PTP61F/PTP1B to its substrate, the IR.
Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
Data show that more than 10,000 phosphorylation sites in the phosphoproteome were detected in Drosophila cells phosphatase Ptp61F knocked down by RNAi.
Title: Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics.
Results establish that PTP61F and dAbl ensure proper actin organization through the coordinated and reversible tyrosine phosphorylation of Kette.
Title: Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl.
Ptp61F is a novel modulator of TOR activity
Title: An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0903 (e-PCR)
- UniSTS:4520

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein sequestering activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IPI Inferred from Physical Interaction more info	PubMed
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein tyrosine phosphatase 61F

Names: CG9181-PA; CG9181-PB; CG9181-PC; CG9181-PD; CG9181-PE; Ptp61F-PA; Ptp61F-PB; Ptp61F-PC; Ptp61F-PD; Ptp61F-PE; cytoplasmic protein tyrosine phosphatase 62A; protein tyrosine phosphatase; protein-tyrosine-phosphatase

NP_001261253.1

EC 3.1.3.-

EC 3.1.3.48

NP_476687.1

EC 3.1.3.-

EC 3.1.3.48

NP_476688.1

EC 3.1.3.-

EC 3.1.3.48

NP_728600.1

EC 3.1.3.-

EC 3.1.3.48

NP_728601.1

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1342493..1475257 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167874.2 → NP_728600.1 protein tyrosine phosphatase 61F, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728600.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMI1

Related

FBpp0072600

Conserved Domains (2) summary

smart00194
Location:30 → 290

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:57 → 290

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_057340.4 → NP_476688.1 protein tyrosine phosphatase 61F, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476688.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMI1

Related

FBpp0072601

Conserved Domains (2) summary

smart00194
Location:34 → 295

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:62 → 295

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001274324.2 → NP_001261253.1 protein tyrosine phosphatase 61F, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261253.1

Status: REVIEWED

UniProtKB/TrEMBL

B8A420, Q8IRH4

Conserved Domains (2) summary

smart00194
Location:1 → 178

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1 → 178

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_167875.2 → NP_728601.1 protein tyrosine phosphatase 61F, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728601.1

Status: REVIEWED

UniProtKB/TrEMBL

B8A420, Q8IRH4

Related

FBpp0072603

Conserved Domains (2) summary

smart00194
Location:1 → 178

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1 → 178

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_057339.5 → NP_476687.1 protein tyrosine phosphatase 61F, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27932, Q8SZY3, Q9W0G1, Q9W0G2

UniProtKB/TrEMBL

D3DMI1, I0B1P6

Related

FBpp0072602

Conserved Domains (2) summary

smart00194
Location:34 → 295

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:62 → 295

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...