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    Fhos Formin homology 2 domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fhosprovided by FlyBase
    Official Full Name
    Formin homology 2 domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266084
    Locus tag
    Dmel_CG42610
    See related
    AllianceGenome:FB:FBgn0266084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32025; CG32030; CG42610; CG5775; CG5797; desert; dFHOS; Dmel\CG42610; fhos; jaz; knit; l(3)01629
    Old locus tag
    Dmel_CG32025; Dmel_CG32030
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including instar larval or pupal morphogenesis; muscle cell cellular homeostasis; and positive regulation of stress fiber assembly. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including adult heart; embryonic/larval dorsal vessel; gland; imaginal disc; and region of integument. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to several human genes including FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fhos in Genome Data Viewer
    Location:
    66D12-66D15; 3-26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8753619..8798719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8746719..8791819)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44527 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Acyl-CoA binding protein 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formin tails act as a switch, inhibiting or enhancing processive actin elongation. Bremer KV, et al. J Biol Chem, 2024 Jan. PMID 38097186, Free PMC Article
    2. Drosophila and human FHOD family formin proteins nucleate actin filaments. Patel AA, et al. J Biol Chem, 2018 Jan 12. PMID 29127202, Free PMC Article
    3. (CCUG)(n) RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis. Yenigun VB, et al. Dis Model Mech, 2017 Aug 1. PMID 28623239, Free PMC Article
    4. Microtubules provide guidance cues for myofibril and sarcomere assembly and growth. Dhanyasi N, et al. Dev Dyn, 2021 Jan. PMID 32725855
    5. Fhos encodes a Drosophila Formin-like protein participating in autophagic programmed cell death. Anhezini L, et al. Genesis, 2012 Sep. PMID 22422652

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using genetic approaches the authors have identified Fhos, the single Drosophila homolog of the FHOD sub-family of formins, as a primary and versatile mediator of indirect flight muscle thin-filament organization.
      Title: The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly.
    2. Fhos is a new ecdysone-regulated gene that is crucial for changes in the actin cytoskeleton during salivary gland elimination in Drosophila.
      Title: Fhos encodes a Drosophila Formin-like protein participating in autophagic programmed cell death.
    3. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 homolog Knittrig in controlling macrophage migration
      Title: The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 8791331-8796682 mobile_element_type = transposon:I{}960

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle system process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in muscle system process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin homology 2 domain containing
    Names
    CG42610-PA
    CG42610-PB
    CG42610-PD
    CG42610-PE
    CG42610-PF
    CG42610-PG
    CG42610-PH
    CG42610-PI
    CG42610-PJ
    Fhos-PA
    Fhos-PB
    Fhos-PD
    Fhos-PE
    Fhos-PF
    Fhos-PG
    Fhos-PH
    Fhos-PI
    Fhos-PJ
    desert
    formin homology 2 domain containing ortholog
    jazigo
    knittrig
    lethal (3) 01629

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8753619..8798719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274670.1 → NP_001261599.1  formin homology 2 domain containing, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI78
      Conserved Domains (2) summary
      pfam02181
      Location:2020 → 2384
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:2357 → 2451
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. NM_001169916.2 → NP_001163387.2  formin homology 2 domain containing, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163387.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI78
      Conserved Domains (2) summary
      pfam02181
      Location:2020 → 2384
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:2357 → 2451
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    3. NM_001259755.1 → NP_001246684.1  formin homology 2 domain containing, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND66
      Conserved Domains (2) summary
      pfam02181
      Location:1236 → 1600
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:1573 → 1667
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. NM_001202143.2 → NP_001189072.1  formin homology 2 domain containing, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSK7, Q8SY43
      Conserved Domains (2) summary
      pfam02181
      Location:885 → 1249
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:1222 → 1316
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    5. NM_001202142.2 → NP_001189071.1  formin homology 2 domain containing, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRS9, Q8SY43
      Conserved Domains (2) summary
      pfam02181
      Location:885 → 1249
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:1222 → 1316
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    6. NM_168293.3 → NP_729410.1  formin homology 2 domain containing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729410.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY43, Q9VSQ1
      Related
      FBpp0291295
      Conserved Domains (2) summary
      pfam02181
      Location:885 → 1249
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:1222 → 1316
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    7. NM_001259754.2 → NP_001246683.1  formin homology 2 domain containing, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFP9, Q8SY43
      Conserved Domains (2) summary
      pfam02181
      Location:644 → 1008
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:981 → 1075
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    8. NM_001259753.2 → NP_001246682.1  formin homology 2 domain containing, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE63, Q8T4F5
      Conserved Domains (2) summary
      pfam02181
      Location:703 → 1067
      FH2; Formin Homology 2 Domain
      pfam16019
      Location:1040 → 1134
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    9. NM_168294.3 → NP_729411.1  formin homology 2 domain containing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY43, Q9VSQ0
      Related
      FBpp0291296
      Conserved Domains (1) summary
      pfam02181
      Location:885 → 1249
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI78 E1JI78
    M9MRS9 M9MRS9
    M9MSK7 M9MSK7
    M9ND66 M9ND66
    M9NE63 M9NE63
    M9NFP9 M9NFP9
    Q8SY43 Q8SY43
    Q8T4F5 Q8T4F5
    Q9NHX5 Q9NHX5
    Q9VSQ0 Q9VSQ0
    Q9VSQ1 Q9VSQ1

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