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    CenB1A Centaurin beta 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CenB1Aprovided by FlyBase
    Official Full Name
    Centaurin beta 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039056
    Locus tag
    Dmel_CG6742
    See related
    AllianceGenome:FB:FBgn0039056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACAP; Cen1ba; cenB1A; CG6742; Dmel\CG6742
    Summary
    Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be located in membrane. Is expressed in several structures, including Malpighian tubule main body primordium; adult Dh44 neuron of pars intercerebralis; anlage in statu nascendi; gut section; and larval ring gland projection neurons. Orthologous to several human genes including ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1) and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CenB1A in Genome Data Viewer
    Location:
    94E1-94E1; 3-78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23118400..23124217)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18944122..18949939)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carrier of Wingless Neighboring gene uncharacterized protein Neighboring gene Ras association family member Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hedgehog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The winged-helix transcription factor JUMU is a haplo-suppressor/triplo-enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster. Hofmann A, et al. Chromosome Res, 2009. PMID 19301136
    2. In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior. Shahidullah M, et al. J Neurosci, 2009 Oct 21. PMID 19846720, Free PMC Article
    3. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
    4. Innervation of the ring gland of Drosophila melanogaster. Siegmund T, et al. J Comp Neurol, 2001 Mar 19. PMID 11223816
    5. Rab11 regulates cell-cell communication during collective cell movements. Ramel D, et al. Nat Cell Biol, 2013 Mar. PMID 23376974, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centaurin beta 1A
    Names
    CG6742-PA
    CG6742-PB
    CenB1A-PA
    CenB1A-PB
    centaurin beta1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23118400..23124217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079734.5 → NP_524458.1  centaurin beta 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0R1, Q9VCQ6
      Related
      FBpp0083761
      Conserved Domains (7) summary
      cd07603
      Location:18 → 217
      BAR_ACAPs; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing proteins
      cd00204
      Location:652 → 768
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:260 → 355
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:259 → 352
      PH; PH domain
      pfam01412
      Location:384 → 497
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:683 → 736
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:687 → 713
      ANK; ANK repeat [structural motif]

    2. NM_170049.4 → NP_732826.2  centaurin beta 1A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732826.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH23, Q7KS50
      Related
      FBpp0083762
      Conserved Domains (6) summary
      cd00204
      Location:422 → 538
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:23 → 125
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:22 → 122
      PH; PH domain
      pfam01412
      Location:154 → 267
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:453 → 506
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:457 → 483
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KS50 Q7KS50
    Q8MSZ5 Q8MSZ5
    Q8T0R1 Q8T0R1
    Q9VCQ6 Q9VCQ6

    Gene LinkOut

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