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    GluRIIE Glutamate receptor IIE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GluRIIEprovided by FlyBase
    Official Full Name
    Glutamate receptor IIEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051201
    Locus tag
    Dmel_CG31201
    See related
    AllianceGenome:FB:FBgn0051201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31201; DmelGluRIIE; Dmel\CG31201; GluR-IIE
    Summary
    Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in abdominal ventral muscle cell; embryonic/larval hypodermal muscle cell; larval somatic muscle cell; and somatic muscle primordium. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIIE in Genome Data Viewer
    Location:
    92F4-92F4; 3-69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20644154..20648716, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16469876..16474438, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hairless Neighboring gene Phosphatidylinositol 3-kinase 92E Neighboring gene Leucine-rich repeat kinase Neighboring gene Glutamate receptor IID Neighboring gene Neprilysin 4 Neighboring gene Cuticular protein 92F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hebbian plasticity guides maturation of glutamate receptor fields in vivo. Ljaschenko D, et al. Cell Rep, 2013 May 30. PMID 23643532
    2. Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Han TH, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25918369, Free PMC Article
    3. The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. Chen K, et al. J Neurosci, 2005 Jul 13. PMID 16014728, Free PMC Article
    4. Activity-dependent site-specific changes of glutamate receptor composition in vivo. Schmid A, et al. Nat Neurosci, 2008 Jun. PMID 18469810
    5. LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Penney J, et al. Nat Commun, 2016 Jul 19. PMID 27432119, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-gated calcium ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-gated receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of synaptic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor IIE
    Names
    CG31201-PB
    GluRIIE-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20644154..20648716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043268.2 → NP_001036733.1  glutamate receptor IIE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI42, Q5U165
      Conserved Domains (4) summary
      cd06382
      Location:42 → 396
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:419 → 790
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:551 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:51 → 382
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI42 Q0KI42

    Gene LinkOut

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