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    COX6CL Cytochrome c oxidase subunit 6C-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX6CLprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 6C-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051644
    Locus tag
    Dmel_CG31644
    See related
    AllianceGenome:FB:FBgn0051644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT20031; CG31644; Dmel\CG31644
    Summary
    Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX6CL in Genome Data Viewer
    Location:
    25F5-25F5; 2-17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5817890..5818443, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5817890..5818443, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44576 Neighboring gene uncharacterized protein Neighboring gene Trissin receptor Neighboring gene rau

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species. Watanabe K, et al. Cell Rep, 2019 Sep 3. PMID 31484071
    2. Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation. Sieglitz F, et al. Sci Signal, 2013 Nov 5. PMID 24194583
    3. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article
    4. Cardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle. Ren M, et al. J Biol Chem, 2023 Oct. PMID 37690688, Free PMC Article
    5. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6C-like
    Names
    CG31644-PA
    CG31644-PB
    CG31644-PC
    COX6CL-PA
    COX6CL-PB
    COX6CL-PC
    NP_001285640.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5817890..5818443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298710.1 → NP_001285639.1  cytochrome c oxidase subunit 6C-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J713
      Conserved Domains (1) summary
      cl02795
      Location:5 → 71
      Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_164663.3 → NP_723121.1  cytochrome c oxidase subunit 6C-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T970
      Related
      FBpp0078790
      Conserved Domains (1) summary
      cd00927
      Location:4 → 73
      Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001298711.1 → NP_001285640.1  cytochrome c oxidase subunit 6C-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD93
      Conserved Domains (1) summary
      cd00927
      Location:9 → 76
      Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T970 Q8T970
    X2J713 X2J713
    X2JD93 X2JD93

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