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    Ptp52F Protein tyrosine phosphatase 52F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptp52Fprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase 52Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034085
    Locus tag
    Dmel_CG18243
    See related
    AllianceGenome:FB:FBgn0034085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18243; CT18044; Dmel\CG18243; DPTP52F; ptp52F; PTP52F
    Summary
    Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in larval midgut cell programmed cell death; motor neuron axon guidance; and response to ecdysone. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; gastric caecum; larval ventral nerve cord; and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ptp52F in Genome Data Viewer
    Location:
    52F3-52F4; 2-78 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16171112..16178307, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12058617..12065812, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lambik Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lissencephaly-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition. Santhanam A, et al. FEBS J, 2013 Jan. PMID 22780963
    2. Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification. Chicote JU, et al. PLoS One, 2017. PMID 28257417, Free PMC Article
    3. Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis. Santhanam A, et al. Mol Cell Biol, 2014 May. PMID 24550005, Free PMC Article
    4. Refolding and simultaneous purification by three-phase partitioning of recombinant proteins from inclusion bodies. Raghava S, et al. Protein Sci, 2008 Nov. PMID 18780821, Free PMC Article
    5. Addition of a polypeptide stretch at the N-terminus improves the expression, stability and solubility of recombinant protein tyrosine phosphatases from Drosophila melanogaster. Madan LL, et al. Protein Expr Purif, 2008 Feb. PMID 18023205

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrates a novel function of PTP52F in regulating ecdysone-directed metamorphosis via enhancement of autophagic and apoptotic cell death in doomed Drosophila midguts.
      Title: Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis.
    2. Data indicate that the expression of PTP52F was specifically restricted to cells located in the midgut.
      Title: Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition.
    3. identified the cell surface receptor Tartan (Trn) as a candidate substrate for the neuronal RPTP Ptp52F by using a modified two-hybrid screen with a substrate-trapping mutant of Ptp52F as "bait"
      Title: The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ecdysone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein tyrosine phosphatase 52F
    Names
    CG18243-PB
    Ptp52F-PB
    NP_611093.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16171112..16178307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137249.4 → NP_611093.2  protein tyrosine phosphatase 52F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611093.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAB3
      Conserved Domains (3) summary
      smart00194
      Location:1100 → 1345
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1125 → 1348
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:648 → 749
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAB3 A1ZAB3

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