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    Frq1 Frequenin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frq1provided by FlyBase
    Official Full Name
    Frequenin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030897
    Locus tag
    Dmel_CG5744
    See related
    AllianceGenome:FB:FBgn0030897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5744; Dmel\CG5744; frq; Frq; frq1; HL-II
    Summary
    Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in neuromuscular junction development and neurotransmitter secretion. Is expressed in several structures, including adult head; brain; lamina; larval ventral nerve cord; and presumptive embryonic/larval system. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Frq1 in Genome Data Viewer
    Location:
    16F7-17A1; 1-59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18155369..18174744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18049402..18068777)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ariadne 1 Neighboring gene uncharacterized protein Neighboring gene andorra Neighboring gene Frequenin 2 Neighboring gene HES-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple roles for frequenin/NCS-1 in synaptic function and development. Dason JS, et al. Mol Neurobiol, 2012 Apr. PMID 22396213
    2. Implication of frequenin in the facilitation of transmitter release in Drosophila. Rivosecchi R, et al. J Physiol, 1994 Jan 15. PMID 7911829, Free PMC Article
    3. Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function. Braunewell KH, et al. Cell Tissue Res, 1999 Jan. PMID 9931348
    4. Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication. Sánchez-Gracia A, et al. BMC Evol Biol, 2010 Feb 19. PMID 20170488, Free PMC Article
    5. Frequenin--a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system. Pongs O, et al. Neuron, 1993 Jul. PMID 8101711

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [review] Stimulation protocols, sources of calcium and expression patterns (presynaptic vs postsynaptic) of Frq may result in the activation of various protein targets, leading to different synaptic effects.
      Title: Multiple roles for frequenin/NCS-1 in synaptic function and development.
    2. Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth.
      Title: Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth.
    3. Synonymous substitutions have been prevalent in the evolution of the coding region of frq1 and frq2, indicating the presence of strong functional constraints following gene duplication.
      Title: Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication.
    4. We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation.
      Title: Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium sensitive guanylate cyclase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium sensitive guanylate cyclase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium sensitive guanylate cyclase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    frequenin 1
    Names
    CG5744-PB
    CG5744-PC
    CG5744-PD
    CG5744-PE
    Frequenin2
    Frq1-PB
    Frq1-PC
    Frq1-PD
    Frq1-PE
    frequenin
    frequentin
    frequinin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18155369..18174744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038764.2 → NP_001033853.1  frequenin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4Q8, P37236
      UniProtKB/TrEMBL
      M9PHW6
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_133043.3 → NP_573271.1  frequenin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4Q8, P37236
      UniProtKB/TrEMBL
      M9PHW6
      Related
      FBpp0074319
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. NM_001272744.1 → NP_001259673.1  frequenin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4Q8, P37236
      UniProtKB/TrEMBL
      M9PHW6
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_001272745.1 → NP_001259674.1  frequenin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259674.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4Q8, P37236
      UniProtKB/TrEMBL
      M9PHW6
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHW6 M9PHW6
    P37236.2 P37236

    Gene LinkOut

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