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    TTLL6A Tubulin tyrosine ligase-like 6A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TTLL6Aprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 6Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034459
    Locus tag
    Dmel_CG16716
    See related
    AllianceGenome:FB:FBgn0034459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.27; CG16716; DmCG16716; Dmel\CG16716; TTLL6
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule bundle formation. Predicted to be active in ciliary basal body. Orthologous to human TTLL13 (tubulin tyrosine ligase like 13) and TTLL6 (tubulin tyrosine ligase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL6A in Genome Data Viewer
    Location:
    56E1-56E1; 2-90 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19593790..19596866)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15481295..15484371)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene smooth Neighboring gene transfer RNA:Glutamic acid-TTC 1-3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44473 Neighboring gene long non-coding RNA:CR44474

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    2. A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells. Ferjoux G, et al. Dev Biol, 2007 May 15. PMID 17418114
    3. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 6A
    Names
    CG16716-PC
    TTLL6A-PC
    NP_611433.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19593790..19596866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137589.4 → NP_611433.3  tubulin tyrosine ligase-like 6A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611433.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBN5, B3DMK7
      Conserved Domains (1) summary
      pfam03133
      Location:181 → 471
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBN5 A1ZBN5
    Q8T420 Q8T420

    Gene LinkOut

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