U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    eIF2Balpha eukaryotic translation initiation factor 2B subunit alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43549, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    eIF2Balphaprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2B subunit alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039726
    Locus tag
    Dmel_CG7883
    See related
    AllianceGenome:FB:FBgn0039726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7883; DeIF2Balpha; Dmel\CG7883; Eif2b; eIF2B-alpha
    Summary
    Enables enzyme regulator activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See eIF2Balpha in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29934582..29935888, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25760304..25761610, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Mannosidase class I c Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13B Neighboring gene Tachykinin-like receptor at 99D

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Reducing the aneuploid cell burden - cell competition and the ribosome connection. Baker NE, et al. Dis Model Mech, 2022 Nov 1. PMID 36444717, Free PMC Article
    2. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
    3. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
    4. Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster. Gradilla AC, et al. Genetics, 2011 Nov. PMID 21900267, Free PMC Article
    5. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Li X, et al. Sci Rep, 2016 Feb 25. PMID 26911346, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    eukaryotic translation initiation factor 2B subunit alpha
    Names
    CG7883-PA
    eIF2B-alpha
    eIF2Balpha-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29934582..29935888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143495.3 → NP_651752.1  eukaryotic translation initiation factor 2B subunit alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GQ89, Q9VAD4
      Related
      FBpp0084874
      Conserved Domains (2) summary
      COG1184
      Location:31 → 305
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:30 → 294
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GQ89 Q9GQ89
    Q9VAD4 Q9VAD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous