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    cold coiled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33237, updated on 17-Dec-2024

    Summary

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    Official Symbol
    coldprovided by FlyBase
    Official Full Name
    coiledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031268
    Locus tag
    Dmel_CG2813
    See related
    AllianceGenome:FB:FBgn0031268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg2813; CG2813; Dmel\CG2813; leaky4
    Summary
    Involved in several processes, including establishment of blood-brain barrier; regulation of tube size, open tracheal system; and septate junction assembly. Located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; adult heart; ectodermal derivative; epidermis; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cold in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (574291..575734)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (574291..575734)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2 Neighboring gene Prothoracicotropic hormone Neighboring gene PvuII-PstI homology 13 Neighboring gene Goosecoid Neighboring gene long non-coding RNA:CR46148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. Hijazi A, et al. PLoS One, 2011 Mar 15. PMID 21423573, Free PMC Article
    2. The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila. Syed MH, et al. J Neurosci, 2011 May 25. PMID 21613501, Free PMC Article
    3. Occluding junctions as novel regulators of tissue mechanics during wound repair. Carvalho L, et al. J Cell Biol, 2018 Dec 3. PMID 30228162, Free PMC Article
    4. ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells. Esmangart de Bournonville T, et al. Elife, 2024 Feb 2. PMID 38305711, Free PMC Article
    5. Boudin trafficking reveals the dynamic internalisation of specific septate junction components in Drosophila. Tempesta C, et al. PLoS One, 2017. PMID 28977027, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of blood-brain barrier IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of blood-brain barrier IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled
    Names
    CG2813-PA
    CG2813-PB
    cold-PA
    cold-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      574291..575734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272909.1 → NP_001259838.1  coiled, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259838.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPR7
      Conserved Domains (1) summary
      cl10471
      Location:26 → 119
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    2. NM_134692.5 → NP_608536.1  coiled, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPR7
      Related
      FBpp0077729
      Conserved Domains (1) summary
      cl10471
      Location:26 → 119
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPR7 Q9VPR7
    Q9VPR7.1

    Gene LinkOut

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