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    Tusp tusp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tuspprovided by FlyBase
    Official Full Name
    tuspprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039530
    Locus tag
    Dmel_CG5586
    See related
    AllianceGenome:FB:FBgn0039530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5586; Dmel\CG5586; DMG2-MB6.chr3R.24.043; TUSP
    Summary
    Involved in SNARE complex assembly and synaptic signaling. Is expressed in adult brain; femoral chordotonal organ; labellum; second segment of antenna; and third segment of antenna. Orthologous to human TULP4 (TUB like protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tusp in Genome Data Viewer
    Location:
    98A10-98A12; 3-94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27607879..27634932)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23433601..23460654)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene distracted Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mig-2-like Neighboring gene mir-1001 stem loop Neighboring gene tau

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family. Ronshaugen M, et al. Mech Dev, 2002 Sep. PMID 12204260
    2. Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila. Yoon EJ, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27888110
    3. Dynamics of Gene Co-expression Networks in Time-Series Data: A Case Study in Drosophila melanogaster Embryogenesis. Lau LY, et al. Front Genet, 2020. PMID 32528531, Free PMC Article
    4. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Baker BM, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074789, Free PMC Article
    5. Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation. Tiwari MD, et al. Biol Open, 2019 Nov 12. PMID 31649115, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest TUSP is a novel regulator of SNARE assembly and, therefore, of neurotransmitter release.
      Title: Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SNARE complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tusp
    Names
    CG5586-PD
    CG5586-PE
    CG5586-PF
    CG5586-PG
    Tusp-PD
    Tusp-PE
    Tusp-PF
    Tusp-PG
    dmWSBa Tubby-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27607879..27634932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202374.2 → NP_001189303.1  tusp, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ2, H0RNI0, Q9VB18
      Conserved Domains (4) summary
      COG2319
      Location:51 → 295
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1354 → 1425
      Tub; Tub family
      sd00039
      Location:91 → 126
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:81 → 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001276085.2 → NP_001263014.1  tusp, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI44, C9QPJ2
      Conserved Domains (4) summary
      COG2319
      Location:51 → 295
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1355 → 1426
      Tub; Tub family
      sd00039
      Location:91 → 126
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:81 → 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001276086.2 → NP_001263015.1  tusp, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHZ3, C9QPJ2
      Conserved Domains (4) summary
      COG2319
      Location:51 → 295
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1352 → 1423
      Tub; Tub family
      sd00039
      Location:91 → 126
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:81 → 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_143316.4 → NP_651573.4  tusp, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651573.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ2, H0RNI0, Q9VB18
      Conserved Domains (4) summary
      COG2319
      Location:51 → 295
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1354 → 1425
      Tub; Tub family
      sd00039
      Location:91 → 126
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:81 → 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHZ3 A0A0B4KHZ3
    A0A0B4KI44 A0A0B4KI44
    Q9VB18 Q9VB18

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