Strump Strumpellin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Strumpprovided by FlyBase
Official Full Name: Strumpellinprovided by FlyBase
Primary source: FLYBASE:FBgn0036571
Locus tag: Dmel_CG12272
See related: AllianceGenome:FB:FBgn0036571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12272; Dmel\CG12272; p118; strump
Summary: Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Is expressed in adult head. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16122002..16126052)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16115102..16119152)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin nucleation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	IEA Inferred from Electronic Annotation more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain