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    Dhc1 Dynein heavy chain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhc1provided by FlyBase
    Official Full Name
    Dynein heavy chain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0287844
    Locus tag
    Dmel_CG9492
    See related
    AllianceGenome:FB:FBgn0287844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9492; DHC3B; DmDhc1; Dmel\CG9492; dnah5; Dnah5
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sensory perception of sound. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in antenna; chordotonal neurons; and spermatozoon. Used to study sensorineural hearing loss. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhc1 in Genome Data Viewer
    Location:
    85E2-85E3; 3-49 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9651179..9674643, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5476901..5500365, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Spermidine Synthase Neighboring gene Sex comb on midleg Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Neprilysin-like 12 Neighboring gene p23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae. Li B, et al. Neurosci Bull, 2021 Apr. PMID 33570705, Free PMC Article
    2. The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Cabrero P, et al. J Exp Biol, 2002 Dec. PMID 12432004
    3. The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology. Wang X, et al. J Neurosci, 2015 Oct 21. PMID 26490864, Free PMC Article
    4. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
    5. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein heavy chain 1
    Names
    CG9492-PD
    CG9492-PE
    CG9492-PF
    CG9492-PG
    Dhc1-PD
    Dhc1-PE
    Dhc1-PF
    Dhc1-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9651179..9674643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260079.2 → NP_001247008.1  dynein heavy chain 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K648
      Conserved Domains (7) summary
      COG5245
      Location:1178 → 4348
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam03028
      Location:4007 → 4689
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:283 → 843
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1458 → 1861
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3276 → 3622
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3650 → 3866
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1994 → 2222
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001300327.1 → NP_001287256.1  dynein heavy chain 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH20
      Conserved Domains (7) summary
      COG5245
      Location:1178 → 4372
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam03028
      Location:4031 → 4713
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:283 → 843
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1458 → 1861
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3300 → 3646
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3674 → 3890
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1994 → 2222
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_141666.5 → NP_649923.4  dynein heavy chain 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649923.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH97
      Conserved Domains (7) summary
      COG5245
      Location:1170 → 4340
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam03028
      Location:3999 → 4681
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:254 → 814
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1450 → 1853
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3268 → 3614
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3642 → 3858
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1986 → 2214
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001260078.2 → NP_001247007.1  dynein heavy chain 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K614
      Conserved Domains (7) summary
      COG5245
      Location:1170 → 4364
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam03028
      Location:4023 → 4705
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:254 → 814
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1450 → 1853
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3292 → 3638
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3666 → 3882
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1986 → 2214
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K614 A0A0B4K614
    A0A0B4K648 A0A0B4K648
    A0A0B4LH20 A0A0B4LH20
    Q9VH97 Q9VH97

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