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    Cirl Calcium-independent receptor for alpha-latrotoxin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cirlprovided by FlyBase
    Official Full Name
    Calcium-independent receptor for alpha-latrotoxinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033313
    Locus tag
    Dmel_CG8639
    See related
    AllianceGenome:FB:FBgn0033313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADGRL3; anon-WO0170980.7; anon-WO0170980.8; BcDNA:GH07331; CG8639; cirl; CIRL; dcirl; dCirl; Dmel\CG8639
    Summary
    Enables mechanoreceptor activity. Involved in adult locomotory behavior and proprioception. Is active in plasma membrane. Is expressed in adult head; campaniform sensillum; larval abdominal lch5 neuron; and larval abdominal multidendritic neurons. Used to study attention deficit hyperactivity disorder. Orthologous to several human genes including ADGRL2 (adhesion G protein-coupled receptor L2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cirl in Genome Data Viewer
    Location:
    44D4-44D5; 2-59 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8614722..8625203)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4502227..4512708)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lunapark Neighboring gene regular Neighboring gene uncharacterized protein Neighboring gene beta-1,3-Galactosyltransferase II Neighboring gene Vacuolar protein sorting 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Model Organisms in G Protein-Coupled Receptor Research. Langenhan T, et al. Mol Pharmacol, 2015 Sep. PMID 25979002, Free PMC Article
    2. High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation. Thane M, et al. Open Biol, 2023 Apr. PMID 37072034, Free PMC Article
    3. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Scholz N, et al. Elife, 2017 Aug 8. PMID 28784204, Free PMC Article
    4. Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Song W, et al. Proc Natl Acad Sci U S A, 2007 Mar 20. PMID 17360325, Free PMC Article
    5. The adhesion GPCR latrophilin/CIRL shapes mechanosensation. Scholz N, et al. Cell Rep, 2015 May 12. PMID 25937282

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.
      Title: Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.
    2. Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
      Title: Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
    3. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
      Title: Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
    4. These results provide direct evidence that the adhesion-type G protein-coupled receptor dCIRL acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response.
      Title: Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons.
    5. dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors of Drosophila.
      Title: The adhesion GPCR latrophilin/CIRL shapes mechanosensation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mechanoreceptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proprioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium-independent receptor for alpha-latrotoxin
    Names
    CG8639-PB
    CG8639-PE
    CG8639-PF
    CG8639-PG
    CG8639-PH
    CG8639-PI
    CG8639-PJ
    CG8639-PK
    Cirl-PB
    Cirl-PE
    Cirl-PF
    Cirl-PG
    Cirl-PH
    Cirl-PI
    Cirl-PJ
    Cirl-PK
    latrophilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8614722..8625203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136553.5 → NP_610397.4  Calcium-independent receptor for alpha-latrotoxin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610397.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7G7, B7YZT6, Q6GKZ7, Q8T3I8
      Conserved Domains (4) summary
      smart00303
      Location:689 → 736
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:17 → 97
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:437 → 664
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:747 → 998
      7tm_4; Olfactory receptor

    2. NM_001259276.2 → NP_001246205.1  Calcium-independent receptor for alpha-latrotoxin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7G7, B7YZT6, Q6GKZ7, Q8T3I8
      UniProtKB/TrEMBL
      A0A0B4K6T3
      Conserved Domains (4) summary
      smart00303
      Location:637 → 684
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:2 → 45
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:385 → 612
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:695 → 946
      7tm_4; Olfactory receptor

    3. NM_001273878.1 → NP_001260807.1  Calcium-independent receptor for alpha-latrotoxin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7G7, B7YZT6, Q6GKZ7, Q8T3I8
      UniProtKB/TrEMBL
      A0A0B4KEG9
      Conserved Domains (4) summary
      smart00303
      Location:705 → 752
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:33 → 113
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:453 → 680
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:763 → 1014
      7tm_4; Olfactory receptor

    4. NM_001273880.2 → NP_001260809.1  Calcium-independent receptor for alpha-latrotoxin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U8, F7VJV3
      Conserved Domains (3) summary
      smart00303
      Location:633 → 680
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:2 → 45
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:385 → 608
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    5. NM_001273879.2 → NP_001260808.1  Calcium-independent receptor for alpha-latrotoxin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEF5, F7VJV3
      Conserved Domains (3) summary
      smart00303
      Location:701 → 748
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:33 → 113
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:453 → 676
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    6. NM_001144148.4 → NP_001137620.1  Calcium-independent receptor for alpha-latrotoxin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7G7, B7YZT6, Q6GKZ7, Q8T3I8
      UniProtKB/TrEMBL
      A0A0B4K6T3
      Conserved Domains (4) summary
      smart00303
      Location:637 → 684
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:2 → 45
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:385 → 612
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:695 → 946
      7tm_4; Olfactory receptor

    7. NM_001169619.4 → NP_001163090.1  Calcium-independent receptor for alpha-latrotoxin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7G7, B7YZT6, Q6GKZ7, Q8T3I8
      UniProtKB/TrEMBL
      E1JH11
      Conserved Domains (4) summary
      smart00303
      Location:633 → 680
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:2 → 45
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:385 → 608
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:691 → 942
      7tm_4; Olfactory receptor

    8. NM_001259275.2 → NP_001246204.1  Calcium-independent receptor for alpha-latrotoxin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U8, F7VJV3
      Conserved Domains (3) summary
      smart00303
      Location:633 → 680
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02140
      Location:2 → 45
      Gal_Lectin; Galactose binding lectin domain
      pfam16489
      Location:385 → 608
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6T3 A0A0B4K6T3
    A0A0B4K7U8 A0A0B4K7U8
    A0A0B4KEF5 A0A0B4KEF5
    A0A0B4KEG9 A0A0B4KEG9
    A1Z7G7.2 A1Z7G7
    E1JH11 E1JH11

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