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    Ncoa6 Nuclear receptor coactivator 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ncoa6provided by FlyBase
    Official Full Name
    Nuclear receptor coactivator 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0031698
    Locus tag
    Dmel_CG14023
    See related
    AllianceGenome:FB:FBgn0031698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1402; CG14023; Dmel\CG14023; dNCOA6; NcoA6; NCOA6
    Summary
    Enables transcription coactivator binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ncoa6 in Genome Data Viewer
    Location:
    25D5-25D6; 2-16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5315290..5326683, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5315290..5326683, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene vrille Neighboring gene long non-coding RNA:CR45730 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44985 Neighboring gene uncharacterized protein Neighboring gene cyclope

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. Qing Y, et al. Elife, 2014 Jul 15. PMID 25027438, Free PMC Article
    2. Yorkie promotes transcription by recruiting a histone methyltransferase complex. Oh H, et al. Cell Rep, 2014 Jul 24. PMID 25017066, Free PMC Article
    3. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
    4. Modulation of Yorkie activity by alternative splicing is required for developmental stability. Srivastava D, et al. EMBO J, 2021 Feb 1. PMID 33320356, Free PMC Article
    5. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recruitment of NcoA6 is necessary and sufficient for transcriptional activation.
      Title: Yorkie promotes transcription by recruiting a histone methyltransferase complex.
    2. Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6
      Title: The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 6
    Names
    CG14023-PC
    CG14023-PD
    CG14023-PF
    Ncoa6-PC
    Ncoa6-PD
    Ncoa6-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5315290..5326683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258955.2 → NP_001245884.1  nuclear receptor coactivator 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NES4
      Conserved Domains (1) summary
      pfam13820
      Location:12 → 64
      Nucleic_acid_bd; Putative nucleic acid-binding region

    2. NM_001103618.3 → NP_001097088.3  nuclear receptor coactivator 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097088.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYV5
      Conserved Domains (1) summary
      pfam13820
      Location:12 → 64
      Nucleic_acid_bd; Putative nucleic acid-binding region

    3. NM_135077.3 → NP_608921.3  nuclear receptor coactivator 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608921.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMS2
      Conserved Domains (1) summary
      pfam13820
      Location:11 → 63
      Nucleic_acid_bd; Putative nucleic acid-binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYV5 A8DYV5
    M9NES4 M9NES4
    Q8MSY0 Q8MSY0
    Q9VMS2 Q9VMS2

    Gene LinkOut

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