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    CG10927 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10927provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034360
    Locus tag
    Dmel_CG10927
    See related
    AllianceGenome:FB:FBgn0034360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10927
    Summary
    Predicted to enable tRNA-specific adenosine deaminase activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be part of tRNA-specific adenosine-34 deaminase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10927 in Genome Data Viewer
    Location:
    55E1-55E2; 2-86 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18613090..18614255)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14500595..14501760)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46271 Neighboring gene Rad, Gem/Kir family member 2 Neighboring gene Guanine nucleotide exchange factor in mesoderm Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA editing by base deamination: more enzymes, more targets, new mysteries. Gerber AP, et al. Trends Biochem Sci, 2001 Jun. PMID 11406411
    2. Genetic modifiers of tauopathy in Drosophila. Shulman JM, et al. Genetics, 2003 Nov. PMID 14668378, Free PMC Article
    3. A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines. Hsu HJ, et al. Gene Expr Patterns, 2017 Jan. PMID 28093350, Free PMC Article
    4. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA-specific adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-specific adenosine-34 deaminase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10927-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18613090..18614255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137501.3 → NP_611345.1  uncharacterized protein Dmel_CG10927 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K157
      Related
      FBpp0085884
      Conserved Domains (1) summary
      cl00269
      Location:274 → 350
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K157 Q7K157

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