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    CG12084 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 192509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12084provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043458
    Locus tag
    Dmel_CG12084
    See related
    AllianceGenome:FB:FBgn0043458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD02105; Dmel\CG12084; LD02105
    Summary
    Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12084 in Genome Data Viewer
    Location:
    62A2-62A2; 3-0.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1490951..1496643, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1490951..1496643, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene stem cell tumor Neighboring gene ncRNA Neighboring gene small non-coding RNA:CR43701 Neighboring gene antisense RNA:CR45812 Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene half pint Neighboring gene Puromycin sensitive aminopeptidase Neighboring gene cueball

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination. Wang X, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30606799, Free PMC Article
    2. An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Tseng AS, et al. Genetics, 2002 Sep. PMID 12242236, Free PMC Article
    3. A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Abdelilah-Seyfried S, et al. Genetics, 2000 Jun. PMID 10835395, Free PMC Article
    4. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
    5. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12084-PA
    CG12084-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1490951..1496643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274328.1 → NP_001261257.1  uncharacterized protein Dmel_CG12084, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBH9
      Conserved Domains (2) summary
      cd00020
      Location:535 → 643
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00034
      Location:110 → 135
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_138268.2 → NP_612112.1  uncharacterized protein Dmel_CG12084, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0E8
      Related
      FBpp0072595
      Conserved Domains (2) summary
      cd00020
      Location:535 → 628
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00034
      Location:110 → 135
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBH9 M9PBH9
    Q9W0E8.2 Q9W0E8

    Gene LinkOut

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