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    AcCoAS Acetyl Coenzyme A synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AcCoASprovided by FlyBase
    Official Full Name
    Acetyl Coenzyme A synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0012034
    Locus tag
    Dmel_CG9390
    See related
    AllianceGenome:FB:FBgn0012034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AcCoAs; ACeCS1; acs; ACS; BEST:GH28401; CG9390; dACS; Dmel\CG9390
    Summary
    Predicted to enable acetate-CoA ligase activity. Involved in behavioral response to ethanol and photoreceptor cell maintenance. Is expressed in adult head. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AcCoAS in Genome Data Viewer
    Location:
    78C3-78C4; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21270722..21280243, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21263822..21273343, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene pumpless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the AMP-forming acetyl-CoA synthetase gene in the Drosophilidae family. Karan D, et al. J Mol Evol, 2003. PMID 15008428
    2. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
    3. Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system. Zinke I, et al. Development, 1999 Dec. PMID 10556053
    4. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663, Free PMC Article
    5. The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina. Lyu J, et al. Cell Death Differ, 2021 Feb. PMID 32913227, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from acetate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetyl coenzyme A synthase
    Names
    Ac CoA synthase
    AcCoA synthetase
    AcCoAS-PA
    AcCoAS-PB
    AcCoAS-PD
    Acetyl-CoA synthase
    Acetyl-CoA sythase
    AcetylCoA synthase
    CG9390-PA
    CG9390-PB
    CG9390-PD
    acetate-coenzyme A ligase
    acetyl CoA synthase
    acetyl CoA synthetase
    acetyl-CoA synthetase
    acetyl-coenzyme A synthase
    NP_001014599.2
    NP_524196.2
    NP_730611.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21270722..21280243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168894.3 → NP_730611.1  acetyl coenzyme A synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24226, Q8IH30, Q9VP60, Q9VP61
      UniProtKB/TrEMBL
      F3YDG9, Q59E09
      Related
      FBpp0078067
      Conserved Domains (2) summary
      cd05966
      Location:30 → 654
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PRK00174
      Location:7 → 665
      PRK00174; acetyl-CoA synthetase; Provisional

    2. NM_001014599.2 → NP_001014599.2  acetyl coenzyme A synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014599.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24226, Q8IH30, Q9VP60, Q9VP61
      UniProtKB/TrEMBL
      F3YDG9, Q59E09
      Conserved Domains (2) summary
      cd05966
      Location:30 → 654
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PRK00174
      Location:7 → 665
      PRK00174; acetyl-CoA synthetase; Provisional

    3. NM_079472.3 → NP_524196.2  acetyl coenzyme A synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524196.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VP61
      Related
      FBpp0078068
      Conserved Domains (2) summary
      cd05966
      Location:1 → 508
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PLN03051
      Location:1 → 491
      PLN03051; acyl-activating enzyme; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59E09 Q59E09
    Q9VP61.1 Q9VP61

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