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    CG42271 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42271provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259166
    Locus tag
    Dmel_CG42271
    See related
    AllianceGenome:FB:FBgn0259166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1846; CG33248; CG33249; Dmel\CG42271; FBgn0259166; INPP4A
    Old locus tag
    Dmel_CG33248; Dmel_CG33249
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be active in cytoplasm. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A) and INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42271 in Genome Data Viewer
    Location:
    12E5-12E5; 1-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14228060..14234066, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14122093..14128099, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 16 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene F box and leucine-rich-repeat gene 4 Neighboring gene Dihydrouridine synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
    2. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. Wishart TM, et al. PLoS Genet, 2012. PMID 22952455, Free PMC Article
    3. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
    4. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article
    5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42271-PB
    CG42271-PC
    NP_996434.2
    NP_996435.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14228060..14234066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206711.3 → NP_996434.2  uncharacterized protein Dmel_CG42271, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996434.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY47
      Conserved Domains (3) summary
      cd13272
      Location:1 → 145
      PH_INPP4A_INPP4B; Type I inositol 3,4-bisphosphate 4-phosphatase and Type II inositol 3,4-bisphosphate 4-phosphatase Pleckstrin homology (PH) domain
      pfam00169
      Location:21 → 123
      PH; PH domain
      cl14603
      Location:201 → 318
      C2; C2 domain

    2. NM_206712.2 → NP_996435.1  uncharacterized protein Dmel_CG42271, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR65
      Conserved Domains (2) summary
      cd13272
      Location:1 → 145
      PH_INPP4A_INPP4B; Type I inositol 3,4-bisphosphate 4-phosphatase and Type II inositol 3,4-bisphosphate 4-phosphatase Pleckstrin homology (PH) domain
      pfam00169
      Location:21 → 123
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR65 Q8MR65
    Q9VY47 Q9VY47

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