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    CG10366 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10366provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032814
    Locus tag
    Dmel_CG10366
    See related
    AllianceGenome:FB:FBgn0032814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10366
    Summary
    Enables DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10366 in Genome Data Viewer
    Location:
    37F2-37F2; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19584235..19586440)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19584235..19586440)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hakai Neighboring gene long non-coding RNA:CR44978 Neighboring gene Proliferating cell nuclear antigen 2 Neighboring gene Leukocyte-antigen-related-like Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Chen LY, et al. Curr Biol, 2006 Jun 20. PMID 16782008
    2. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
    3. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article
    4. Genome-wide mapping of in vivo targets of the Drosophila transcription factor Kruppel. Matyash A, et al. J Biol Chem, 2004 Jul 16. PMID 15131112
    5. ZAD-Domain Is Essential for Nuclear Localization of Insulator Proteins in Drosophila melanogaster. Zolotarev NA, et al. Acta Naturae, 2016 Jul-Sep. PMID 27795848, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10366-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19584235..19586440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136151.3 → NP_609995.1  uncharacterized protein Dmel_CG10366 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR68, Q9VIS9
      Related
      FBpp0080800
      Conserved Domains (6) summary
      COG5048
      Location:222 → 408
      COG5048; FOG: Zn-finger [General function prediction only]
      PTZ00423
      Location:131 → 230
      PTZ00423; glideosome-associated protein 45; Provisional
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:418 → 440
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:28 → 108
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR68 Q8MR68
    Q9VIS9 Q9VIS9

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