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    SP2353 SP2353 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SP2353provided by FlyBase
    Official Full Name
    SP2353provided by FlyBase
    Primary source
    FLYBASE:FBgn0034070
    Locus tag
    Dmel_CG8403
    See related
    AllianceGenome:FB:FBgn0034070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH12319; CG8403; CT18665; Dmel\CG8403; Hspg2
    Summary
    Predicted to enable calcium ion binding activity. Involved in muscle cell cellular homeostasis and rhabdomere development. Predicted to be located in extracellular matrix. Orthologous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SP2353 in Genome Data Viewer
    Location:
    52D15-52E1; 2-76 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16031930..16047243)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11919435..11934748)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene caspar Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-137 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina. Husain N, et al. Dev Cell, 2006 Oct. PMID 17011488
    2. An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila. Liu Z, et al. Mol Brain, 2020 Jan 3. PMID 31900209, Free PMC Article
    3. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. Marrone AK, et al. BMC Neurosci, 2011 Sep 26. PMID 21943192, Free PMC Article
    4. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Kucherenko MM, et al. Dev Biol, 2011 Apr 15. PMID 21256839
    5. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SP2353
    Names
    CG8403-PA
    CG8403-PB
    SP2353-PA
    SP2353-PB
    agrin-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16031930..16047243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299545.1 → NP_001286474.1  SP2353, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA87, Q9NGV2
      Conserved Domains (4) summary
      smart00282
      Location:1205 → 1340
      LamG; Laminin G domain
      cd00110
      Location:625 → 774
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:583 → 612
      EGF; EGF-like domain
      pfam14670
      Location:53 → 82
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. NM_137238.4 → NP_611082.2  SP2353, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611082.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA87, Q9NGV2
      Related
      FBpp0086351
      Conserved Domains (4) summary
      smart00282
      Location:1205 → 1340
      LamG; Laminin G domain
      cd00110
      Location:625 → 774
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:583 → 612
      EGF; EGF-like domain
      pfam14670
      Location:53 → 82
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA87 A1ZA87
    Q8MRN8 Q8MRN8
    Q9NGV2 Q9NGV2

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