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    Tm1 Tropomyosin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm1provided by FlyBase
    Official Full Name
    Tropomyosin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0003721
    Locus tag
    Dmel_CG4898
    See related
    AllianceGenome:FB:FBgn0003721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1305/10; 2299; BcDNA:GH09289; BcDNA:LD37158; BcDNA:SD21996; CG4898; chr3R:11122272..11122408; cTm; cTM; cTmII; Dm Tm1; Dm TmH33; Dm TmH34; Dmel\CG4898; DmTm1; l(3)02299; l(3)S130510; l(3)s2958; mTmII; PmI; region 3; Tm; TM; tm1; TM1; TmH; TmH-33; TmH-34; TmH33; TmH34; tmII; TmII; TMII; Tmr33; Tmr34; TnH; TnH-33; TnH-34; tropomyosin
    Summary
    Enables actin filament binding activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including dendrite morphogenesis; pole plasm oskar mRNA localization; and stress fiber assembly. Located in P granule; investment cone; and sarcomere. Colocalizes with cortical actin cytoskeleton and stress fiber. Is expressed in several structures, including epithelium; ganglia; germline cell; gut section; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in blood platelet disease; congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TPM1 (tropomyosin 1) and TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tm1 in Genome Data Viewer
    Location:
    88E11-88E13; 3-56 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15278220..15308779)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11107093..11134501)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene lethal (3) neo43 Neighboring gene MORF-related gene 15 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme does not affect flight ability. Cripps RM, et al. Biochem Genet, 1992 Apr. PMID 1590747
    2. An Atypical Tropomyosin in Drosophila with Intermediate Filament-like Properties. Cho A, et al. Cell Rep, 2016 Jul 26. PMID 27396338, Free PMC Article
    3. Developmental regulation of the Drosophila tropomyosin II gene in different muscles is controlled by muscle-type-specific intron enhancer elements and distal and proximal promoter control elements. Meredith J, et al. Dev Biol, 1993 Oct. PMID 8405674
    4. Transcriptional and post-transcriptional regulation of maternal and zygotic cytoskeletal tropomyosin mRNA during Drosophila development correlates with specific morphogenic events. Hales KH, et al. Dev Biol, 1994 Oct. PMID 7958428
    5. Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments. Sysoev VO, et al. Proc Natl Acad Sci U S A, 2020 Sep 22. PMID 32907935, Free PMC Article

    See all (246) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tm1C-Khc interaction is specific for the osk localization pathway.
      Title: A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization.
    2. The authors demonstrate that kinesin-1 recruitment requires the DmTropomyosin1-I/C isoform, an atypical RNA-binding tropomyosin that binds directly to dimerizing oskar 3'UTRs.
      Title: An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.
    3. analysis of arrhythmia caused by a Drosophila tropomyosin mutation using optical coherence tomography
      Title: Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument.
    4. We report here that tropomyosins are post-translationally modified by several phosphorylations in their C-termini in mature flies, but not in recently emerged flies that are incapable of flight.
      Title: The structural role of high molecular weight tropomyosins in dipteran indirect flight muscle and the effect of phosphorylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cortical actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in investment cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with stress fiber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tropomyosin 1
    Names
    CG4898-PA
    CG4898-PC
    CG4898-PE
    CG4898-PF
    CG4898-PG
    CG4898-PH
    CG4898-PI
    CG4898-PJ
    CG4898-PK
    CG4898-PL
    CG4898-PM
    CG4898-PN
    CG4898-PO
    CG4898-PP
    CG4898-PQ
    CG4898-PR
    CG4898-PS
    CG4898-PT
    Tm1-PA
    Tm1-PC
    Tm1-PE
    Tm1-PF
    Tm1-PG
    Tm1-PH
    Tm1-PI
    Tm1-PJ
    Tm1-PK
    Tm1-PL
    Tm1-PM
    Tm1-PN
    Tm1-PO
    Tm1-PP
    Tm1-PQ
    Tm1-PR
    Tm1-PS
    Tm1-PT
    Tropomyosin-1
    Tropomyosin1
    cytoplasmic tropomyosin
    cytoskeletal tropomyosin
    tropomyosin
    tropomyosin I
    tropomyosin II
    tropomyosinII
    tropomysin II
    troponin H
    troponin-H
    troponin-H isoform 34

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15278220..15308779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382175.1 → NP_001369014.1  tropomyosin 1, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EG56
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 275
      Tropomyosin

    2. NM_169635.3 → NP_732003.1  tropomyosin 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Related
      FBpp0088903
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    3. NM_206495.2 → NP_996217.1  tropomyosin 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49455, P49456, Q24425, Q24426, Q7KSH9, Q7KSI0
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin; Tropomyosin

    4. NM_169637.4 → NP_732005.2  tropomyosin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732005.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUP7, Q058U3
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin; Tropomyosin

    5. NM_001260190.1 → NP_001247119.1  tropomyosin 1, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Y8
      Conserved Domains (2) summary
      pfam08537
      Location:2 → 106
      NBP1; Fungal Nap binding protein NBP1
      pfam12718
      Location:7 → 127
      Tropomyosin_1; Tropomyosin like

    6. NM_169633.5 → NP_732001.3  tropomyosin 1, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732001.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    7. NM_169638.4 → NP_732006.2  tropomyosin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732006.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGY1, Q8INE5
      Related
      FBpp0088904
      Conserved Domains (1) summary
      pfam12718
      Location:517 → 648
      Tropomyosin_1; Tropomyosin like

    8. NM_001275662.1 → NP_001262591.1  tropomyosin 1, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG06
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    9. NM_001170148.2 → NP_001163619.1  tropomyosin 1, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN28
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    10. NM_169634.3 → NP_732002.1  tropomyosin 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Related
      FBpp0291171
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    11. NM_169636.3 → NP_732004.1  tropomyosin 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732004.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Related
      FBpp0088906
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    12. NM_206494.3 → NP_996216.1  tropomyosin 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    13. NM_169639.3 → NP_732007.2  tropomyosin 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732007.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG84, Q8INE4
      Related
      FBpp0088902
      Conserved Domains (1) summary
      cl19758
      Location:506 → 612
      FH2; Formin Homology 2 Domain

    14. NM_169640.4 → NP_732008.1  tropomyosin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TA3
      Related
      FBpp0088901
      Conserved Domains (1) summary
      cl19758
      Location:269 → 375
      FH2; Formin Homology 2 Domain

    15. NM_169641.4 → NP_732009.2  tropomyosin 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732009.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TA3
      Related
      FBpp0088900
      Conserved Domains (1) summary
      cl19758
      Location:269 → 375
      FH2; Formin Homology 2 Domain

    16. NM_079636.4 → NP_524360.2  tropomyosin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06754
      Related
      FBpp0088899
      Conserved Domains (1) summary
      pfam00261
      Location:16 → 250
      Tropomyosin

    17. NM_001275661.1 → NP_001262590.1  tropomyosin 1, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG68
      Conserved Domains (1) summary
      pfam00261
      Location:16 → 243
      Tropomyosin

    18. NM_001260191.1 → NP_001247120.1  tropomyosin 1, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K661, C1C3D3
      Conserved Domains (1) summary
      pfam00261
      Location:16 → 243
      Tropomyosin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K661 A0A0B4K661
    A0A0B4K6Y8 A0A0B4K6Y8
    A0A0B4KG06 A0A0B4KG06
    A0A0B4KG68 A0A0B4KG68
    A0A6H2EG56 A0A6H2EG56
    P06754.2 P06754
    P49455.2 P49455
    Q6LEH1 Q6LEH1
    Q6NN28 Q6NN28
    Q8IG84 Q8IG84
    Q8IGY1 Q8IGY1
    Q95TA3 Q95TA3

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