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    Mad1 Mitotic arrest-deficient 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mad1provided by FlyBase
    Official Full Name
    Mitotic arrest-deficient 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026326
    Locus tag
    Dmel_CG2072
    See related
    AllianceGenome:FB:FBgn0026326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2072; Dmel\CG2072; mad1; TXBP181-like
    Summary
    Involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle assembly checkpoint signaling. Located in kinetochore; nuclear envelope; and nucleoplasm. Colocalizes with mitotic spindle. Is expressed in several structures, including anterior endoderm; cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study microcephaly. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mad1 in Genome Data Viewer
    Location:
    45C4-45C4; 2-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9288957..9291565, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5176462..5179070, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Protein kinase N Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45132 Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 6 Neighboring gene DNA fragmentation factor-related protein 2 Neighboring gene Myd88

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila. Raich N, et al. Open Biol, 2018 Oct 17. PMID 30333236, Free PMC Article
    2. Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Ye AA, et al. Curr Biol, 2015 Jul 20. PMID 26166783, Free PMC Article
    3. Insights from an erroneous kinetochore-microtubule attachment state. Cane S, et al. Bioarchitecture, 2013 May-Jun. PMID 23887229, Free PMC Article
    4. RZZ and Mad1 dynamics in Drosophila mitosis. Défachelles L, et al. Chromosome Res, 2015 Jun. PMID 25772408, Free PMC Article
    5. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Cunha-Silva S, et al. J Cell Biol, 2020 Mar 2. PMID 31913420, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
      Title: Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
    2. these results suggest that Drosophila Mad1, by helping organize its interphase protein partners in the nucleoplasm, contributes to proper chromatin regulation.
      Title: Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic arrest-deficient 1
    Names
    CG2072-PA
    Mad1-PA
    TXBP181-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9288957..9291565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136633.4 → NP_610477.2  mitotic arrest-deficient 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610477.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KND8, Q95S25
      Related
      FBpp0087680
      Conserved Domains (1) summary
      pfam05557
      Location:80 → 726
      MAD; Mitotic checkpoint protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KND8 Q7KND8
    Q95S25 Q95S25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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