Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3gl1provided by RGD
Official Full Name: SH3 domain containing GRB2 like 1, endophilin A2provided by RGD
Primary source: RGD:708456
See related: EnsemblRapid:ENSRNOG00000049683 AllianceGenome:RGD:708456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SH3P8
Summary: Enables several functions, including SH3 domain binding activity; beta-1 adrenergic receptor binding activity; and enzyme binding activity. Involved in modulation of excitatory postsynaptic potential and positive regulation of synaptic vesicle endocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Used to study high grade glioma. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 233.8), Thymus (RPKM 175.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (929459..956922, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (842285..869753, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (11031847..11055285)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Title: Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes.
Title: EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes.
EndoA2 inhibited hydrogen peroxide-induced apoptosis in H9C2 cardiomyocytes.
Title: Autophagy is involved in the protective effect of endophilin A2 on H(2)O(2)-induced apoptosis in H9C2 cardiomyocytes.
Study demonstrates that endophilin2 does not contribute to constitutive AMPA receptor endocytosis.
Title: Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β.
results establish a novel function of endoA2 in clathrin-independent endocytosis
Title: Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.
Endophilins II and I interact with the N-type Ca2+ channel C-terminal fragments in clathrin-mediated endocytosis.
Title: Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-1 adrenergic receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in modulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle uncoating	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endophilin-A2

Names: SH3 domain protein 2B; SH3 domain-containing GRB2-like 1; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; endophilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031239.3 → NP_112518.1 endophilin-A2

See identical proteins and their annotated locations for NP_112518.1

Status: VALIDATED

Source sequence(s)

BC070893, CB615317

UniProtKB/Swiss-Prot

O35964

UniProtKB/TrEMBL

A0A8I5YC58, A6KR11

Related

ENSRNOP00000066789.2, ENSRNOT00000074695.4

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:309 → 363

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

929459..956922 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267775.1 → XP_063123845.1 endophilin-A2 isoform X3
XM_039084253.2 → XP_038940181.1 endophilin-A2 isoform X1

UniProtKB/TrEMBL

A0A8I5YC58

Related

ENSRNOP00000084032.2, ENSRNOT00000110808.2

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cl17036
Location:309 → 342

SH3; Src Homology 3 domain superfamily
XM_039084254.2 → XP_038940182.1 endophilin-A2 isoform X2

UniProtKB/TrEMBL

A0A8I5YC58

Conserved Domains (2) summary

cd11803
Location:261 → 315

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

cl12013
Location:25 → 199

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature