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    Ppdpf pancreatic progenitor cell differentiation and proliferation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppdpfprovided by RGD
    Official Full Name
    pancreatic progenitor cell differentiation and proliferation factorprovided by RGD
    Primary source
    RGD:1310660
    See related
    EnsemblRapid:ENSRNOG00000012722 AllianceGenome:RGD:1310660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310660
    Summary
    Predicted to be involved in cell differentiation. Predicted to act upstream of or within TORC1 signaling and liver development. Predicted to be located in mitochondrion. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 171.9), Lung (RPKM 149.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppdpf in Genome Data Viewer
    Location:
    3q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188676821..188678599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168299309..168301040)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176690507..176692272)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene uncharacterized LOC134486215 Neighboring gene protein tyrosine kinase 6 Neighboring gene uncharacterized LOC108350541 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108808

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pancreatic progenitor cell differentiation and proliferation factor
    Names
    exocrine differentiation and proliferation factor
    pancreatic progenitor cell differentiation and proliferation factor homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009316.2 → NP_001009316.1  pancreatic progenitor cell differentiation and proliferation factor

      See identical proteins and their annotated locations for NP_001009316.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5PR01
      UniProtKB/TrEMBL
      A6KM38
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 111
      PPDFL; Differentiation and proliferation regulator

    2. NM_001431549.1 → NP_001418478.1  pancreatic progenitor cell differentiation and proliferation factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5PR01
      UniProtKB/TrEMBL
      A6KM38

    3. NM_001431550.1 → NP_001418479.1  pancreatic progenitor cell differentiation and proliferation factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5PR01
      UniProtKB/TrEMBL
      A6KM38

    4. NM_001431551.1 → NP_001418480.1  pancreatic progenitor cell differentiation and proliferation factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5PR01
      UniProtKB/TrEMBL
      A6KM38

    5. NM_001431552.1 → NP_001418481.1  pancreatic progenitor cell differentiation and proliferation factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5PR01
      UniProtKB/TrEMBL
      A6KM38

    RNA

    1. NR_197231.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NR_197232.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NR_197233.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NR_197234.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188676821..188678599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235748.5 → XP_006235810.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

      Related
      ENSRNOP00000017319.3, ENSRNOT00000017319.7
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 111
      PPDFL; Differentiation and proliferation regulator

    2. XM_006235746.5 → XP_006235808.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

      Conserved Domains (1) summary
      pfam15060
      Location:1 → 111
      PPDFL; Differentiation and proliferation regulator

    3. XM_039104694.2 → XP_038960622.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

      Conserved Domains (1) summary
      pfam15060
      Location:1 → 111
      PPDFL; Differentiation and proliferation regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PR01.1 GenPept UniProtKB/Swiss-Prot:Q5PR01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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