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    Itpkb inositol 1,4,5-trisphosphate 3-kinase B [ Mus musculus (house mouse) ]

    Gene ID: 320404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itpkbprovided by MGI
    Official Full Name
    inositol 1,4,5-trisphosphate 3-kinase Bprovided by MGI
    Primary source
    MGI:MGI:109235
    See related
    Ensembl:ENSMUSG00000038855 AllianceGenome:MGI:109235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110033J02Rik; E130307H12Rik
    Summary
    Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 21.8), thymus adult (RPKM 19.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itpkb in Genome Data Viewer
    Location:
    1 H4; 1 84.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180156655..180252367)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180330390..180424802)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5867 Neighboring gene presenilin 2 Neighboring gene STARR-positive B cell enhancer ABC_E5868 Neighboring gene predicted gene, 31728 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182226418-182226527 Neighboring gene predicted gene, 39713 Neighboring gene STARR-positive B cell enhancer ABC_E3341 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182286358-182286687 Neighboring gene STARR-positive B cell enhancer ABC_E2591 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182296519-182296775 Neighboring gene STARR-positive B cell enhancer ABC_E1575 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182331940-182332241 Neighboring gene STARR-positive B cell enhancer ABC_E5870 Neighboring gene predicted gene, 39712 Neighboring gene STARR-positive B cell enhancer ABC_E5871 Neighboring gene mechanosensory transduction mediator Neighboring gene STARR-positive B cell enhancer ABC_E5872 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182471419-182471720 Neighboring gene STARR-positive B cell enhancer ABC_E3342 Neighboring gene predicted gene, 31986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells. Marongiu L, et al. Sci Signal, 2021 Mar 30. PMID 33785611, Free PMC Article
    2. Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. Chamberlain PP, et al. Biochemistry, 2005 Nov 8. PMID 16262249
    3. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Miller AT, et al. Nat Immunol, 2007 May. PMID 17417640
    4. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Jia Y, et al. Immunity, 2007 Sep. PMID 17825589, Free PMC Article
    5. Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction. Miller AT, et al. J Immunol, 2009 Apr 15. PMID 19342645

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
      Title: Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
    2. The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
      Title: The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
    3. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor induced metabolic activation to enforce coincidence-detection of pre-T cell receptor expression and Notch-engagement.
      Title: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
    4. These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.
      Title: Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
    5. Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.
      Title: IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.
    6. Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.
      Title: Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells.
    7. controls survival and prevents anergy in B cells
      Title: Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells.
    8. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
      Title: The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts.
    9. B cells from Itpkb(-/-) Ig hen egg lysozyme mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling
      Title: Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.
    10. InsP3KB is also a physiological modulator of myelopoiesis.
      Title: Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within common myeloid progenitor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol trisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neutrophil apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol-trisphosphate 3-kinase B
    NP_001074644.1
    NP_001405214.1
    NP_001405215.1
    XP_006496965.1
    XP_030110829.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081175.2 → NP_001074644.1  inositol-trisphosphate 3-kinase B isoform a

      See identical proteins and their annotated locations for NP_001074644.1

      Status: VALIDATED

      Source sequence(s)
      AC121838
      Consensus CDS
      CCDS35808.1
      UniProtKB/TrEMBL
      B2RXC2
      Related
      ENSMUSP00000069851.7, ENSMUST00000070181.7
      Conserved Domains (2) summary
      PHA03307
      Location:24 → 317
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam03770
      Location:722 → 933
      IPK; Inositol polyphosphate kinase

    2. NM_001418285.1 → NP_001405214.1  inositol-trisphosphate 3-kinase B isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121838
      UniProtKB/TrEMBL
      B2RXC2

    3. NM_001418286.1 → NP_001405215.1  inositol-trisphosphate 3-kinase B isoform b

      Status: VALIDATED

      Source sequence(s)
      AC121838

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180156655..180252367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496902.5 → XP_006496965.1  inositol-trisphosphate 3-kinase B isoform X2

      UniProtKB/TrEMBL
      Q8BKB2

    2. XM_030254969.2 → XP_030110829.1  inositol-trisphosphate 3-kinase B isoform X1

      UniProtKB/TrEMBL
      B2RXC2
      Conserved Domains (2) summary
      PHA03307
      Location:24 → 317
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam03770
      Location:722 → 933
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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