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    Cdk12 cyclin-dependent kinase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192350, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdk12provided by RGD
    Official Full Name
    cyclin-dependent kinase 12provided by RGD
    Primary source
    RGD:621111
    See related
    EnsemblRapid:ENSRNOG00000006000 AllianceGenome:RGD:621111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hgn; Crk7; Pksc; Crkrs
    Summary
    Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk12 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83697174..83793676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83201177..83256906)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86157186..86210657)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma. Wang C, et al. Gut, 2020 Apr. PMID 31519701
    2. Identification of a novel protein for memory regulation in the hippocampus. Zhang XH, et al. Biochem Biophys Res Commun, 2005 Aug 26. PMID 16009348
    3. Low expression of CDK12 in gastric cancer is correlated with advanced stage and poor outcome. Liu M, et al. Pathol Res Pract, 2020 Jul. PMID 32534699
    4. CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Iorns E, et al. Carcinogenesis, 2009 Oct. PMID 19651820
    5. Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8(+) cell density and CCL12 expression. Ji J, et al. Int J Med Sci, 2019. PMID 31523177, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
      Title: Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin K-CDK12 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin K-CDK12 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 12
    Names
    CDC2-related kinase 7
    CDC2-related protein kinase 7
    Cdc2-related kinase, arginine/serine-rich
    cell division cycle 2-related protein kinase 7
    cell division protein kinase 12
    hippyragranin
    protein kinase for splicing component
    NP_001029039.1
    NP_620271.1
    XP_006247312.1
    XP_006247313.1
    XP_038941089.1
    XP_063124451.1
    XP_063124452.1
    XP_063124453.1
    XP_063124454.1
    XP_063124455.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033867.2 → NP_001029039.1  cyclin-dependent kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_001029039.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q3MJK5, Q8R458
      Related
      ENSRNOP00000105670.1, ENSRNOT00000122409.1
      Conserved Domains (2) summary
      smart00220
      Location:723 → 1016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. NM_138916.2 → NP_620271.1  cyclin-dependent kinase 12 isoform 2

      See identical proteins and their annotated locations for NP_620271.1

      Status: VALIDATED

      Source sequence(s)
      AY072294, BE117540
      UniProtKB/TrEMBL
      A6HIQ9
      Conserved Domains (2) summary
      smart00220
      Location:723 → 1016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83697174..83793676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268383.1 → XP_063124453.1  cyclin-dependent kinase 12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5U7

    2. XM_063268381.1 → XP_063124451.1  cyclin-dependent kinase 12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5U7

    3. XM_063268382.1 → XP_063124452.1  cyclin-dependent kinase 12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5U7

    4. XM_063268384.1 → XP_063124454.1  cyclin-dependent kinase 12 isoform X4

    5. XM_063268385.1 → XP_063124455.1  cyclin-dependent kinase 12 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AHH6
      Related
      ENSRNOP00000087177.2, ENSRNOT00000114817.2

    6. XM_006247251.5 → XP_006247313.1  cyclin-dependent kinase 12 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:723 → 1016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    7. XM_006247250.5 → XP_006247312.1  cyclin-dependent kinase 12 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q358
      Related
      ENSRNOP00000008256.3, ENSRNOT00000008256.6
      Conserved Domains (2) summary
      smart00220
      Location:722 → 1015
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:714 → 1015
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    8. XM_039085161.2 → XP_038941089.1  cyclin-dependent kinase 12 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3V7
      Related
      ENSRNOP00000092388.2, ENSRNOT00000105342.2
      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MJK5.1 GenPept UniProtKB/Swiss-Prot:Q3MJK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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