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    Akr1e1 aldo-keto reductase family 1, member E1 [ Mus musculus (house mouse) ]

    Gene ID: 56043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1e1provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member E1provided by MGI
    Primary source
    MGI:MGI:1914758
    See related
    Ensembl:ENSMUSG00000045410 AllianceGenome:MGI:1914758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akr1e2; 1810061I10Rik
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; embryo; and retina. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.4), CNS E11.5 (RPKM 11.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Akr1e1 in Genome Data Viewer
    Location:
    13 A1; 13 2.57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4641122..4659163, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4591123..4609164, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene STARR-seq mESC enhancer starr_33514 Neighboring gene predicted gene, 40657 Neighboring gene aldo-keto reductase family 1, member C21 Neighboring gene ribosomal protein L29, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_33515 Neighboring gene STARR-seq mESC enhancer starr_33516 Neighboring gene predicted gene, 40658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel murine aldo-keto reductase. Bohren KM, et al. Adv Exp Med Biol, 1997. PMID 9059651
    2. Mouse AKR1E1 is an ortholog of pig liver NADPH dependent 1,5-anhydro-D-fructose reductase. Sakuma M, et al. Biosci Biotechnol Biochem, 2008 Mar. PMID 18323634
    3. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Vergnes L, et al. J Lipid Res, 2003 Mar. PMID 12562828
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1,5-anhydro-D-fructose reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1,5-anhydro-D-fructose reductase
    Names
    AF reductase
    aldo-keto reductase family 1 member C-like protein 2
    aldo-keto reductase family 1 member E2
    NP_061347.2
    XP_006516548.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018859.2 → NP_061347.2  1,5-anhydro-D-fructose reductase

      See identical proteins and their annotated locations for NP_061347.2

      Status: VALIDATED

      Source sequence(s)
      AI893997, AK002507, BQ174229
      Consensus CDS
      CCDS26226.1
      UniProtKB/Swiss-Prot
      O09125, Q9DCT1
      UniProtKB/TrEMBL
      Q8CEB6
      Related
      ENSMUSP00000089459.6, ENSMUST00000091848.7
      Conserved Domains (2) summary
      COG0656
      Location:4 → 282
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:4 → 287
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      4641122..4659163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516485.3 → XP_006516548.1  1,5-anhydro-D-fructose reductase isoform X1

      Conserved Domains (1) summary
      cl00470
      Location:17 → 210
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCT1.1 GenPept UniProtKB/Swiss-Prot:Q9DCT1

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