Prss32 serine protease 32 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss32provided by MGI
Official Full Name: serine protease 32provided by MGI
Primary source: MGI:MGI:1917064
See related: Ensembl:ENSMUSG00000048992 AllianceGenome:MGI:1917064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mT5; tryptase-5; 2010001P08Rik
Summary: Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in eye; lymph node; smooth muscle tissue; stomach; and uterus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 658.3), large intestine adult (RPKM 245.7) and 2 other tissues See more
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Genomic context

Location:: 17 A3.3; 17 12.09 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24072746..24078750)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23853772..23859776)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Prss32 (e-PCR), detects polymorphism
- UniSTS:265738

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protease, serine, 32

Names: eosinophil serine protease; protease, serine 32; testisin; tryptase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027220.2 → NP_081496.2 protease, serine, 32 precursor

Status: VALIDATED

Source sequence(s)

AC122821

Consensus CDS

CCDS37477.1

UniProtKB/TrEMBL

E9Q409, Q80X17

Related

ENSMUSP00000050389.8, ENSMUST00000061725.8

Conserved Domains (2) summary

smart00020
Location:53 → 292

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:54 → 295

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...