Akt3 thymoma viral proto-oncogene 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akt3provided by MGI
Official Full Name: thymoma viral proto-oncogene 3provided by MGI
Primary source: MGI:MGI:1345147
See related: Ensembl:ENSMUSG00000019699 AllianceGenome:MGI:1345147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nmf350; D930002M15Rik
Summary: Enables protein serine/threonine kinase activity. Involved in negative regulation of PERK-mediated unfolded protein response; positive regulation of angiogenesis; and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 82.66 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (176847642..177091688, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (177020076..177261781, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrated analyses of 5 mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease.
Title: Integrated analyses of 5 mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease.
Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner.
Title: Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner.
miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis.
Title: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis.
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Title: The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
Title: Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
Title: Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
Title: AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
Title: Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
Title: Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Akt3 (e-PCR), detects polymorphism
- UniSTS:532508

AI851531 (e-PCR)
- UniSTS:164141

35.MMHAP18FRD11.seq (e-PCR)
- UniSTS:124131

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: RAC-gamma serine/threonine-protein kinase

Names: PKB gamma; RAC-PK-gamma; protein kinase Akt-3; protein kinase B gamma

NP_035915.3

EC 2.7.11.1

XP_006496881.1

EC 2.7.11.1

XP_006496882.1

EC 2.7.11.1

XP_011237107.1

EC 2.7.11.1

XP_030109770.1

EC 2.7.11.1

XP_030109777.1

EC 2.7.11.1

XP_036020522.1

EC 2.7.11.1

XP_036020523.1

EC 2.7.11.1

XP_036020524.1

EC 2.7.11.1

XP_036020525.1

EC 2.7.11.1

XP_036020526.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011785.4 → NP_035915.3 RAC-gamma serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_035915.3

Status: VALIDATED

Source sequence(s)

AC130843, AC163009, AK052953, BF455585, CD578931

Consensus CDS

CCDS35799.1

UniProtKB/Swiss-Prot

Q9WUA6

UniProtKB/TrEMBL

Q6NXW0

Related

ENSMUSP00000106790.3, ENSMUST00000111160.9

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

176847642..177091688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164629.1 → XP_036020522.1 RAC-gamma serine/threonine-protein kinase isoform X3

UniProtKB/TrEMBL

Q6NXW0

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:132 → 438

PKc_like; Protein Kinases, catalytic domain
XM_006496818.5 → XP_006496881.1 RAC-gamma serine/threonine-protein kinase isoform X1

See identical proteins and their annotated locations for XP_006496881.1

UniProtKB/Swiss-Prot

Q9WUA6

UniProtKB/TrEMBL

Q6NXW0

Related

ENSMUSP00000106789.2, ENSMUST00000111159.2

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_036164632.1 → XP_036020525.1 RAC-gamma serine/threonine-protein kinase isoform X7

Conserved Domains (1) summary

cl21453
Location:46 → 292

PKc_like; Protein Kinases, catalytic domain
XM_036164631.1 → XP_036020524.1 RAC-gamma serine/threonine-protein kinase isoform X6

Conserved Domains (1) summary

cd05593
Location:16 → 363

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_036164630.1 → XP_036020523.1 RAC-gamma serine/threonine-protein kinase isoform X5

Conserved Domains (2) summary

cl17171
Location:1 → 49

PH-like; Pleckstrin homology-like domain

cl21453
Location:71 → 377

PKc_like; Protein Kinases, catalytic domain
XM_030253917.2 → XP_030109777.1 RAC-gamma serine/threonine-protein kinase isoform X4

UniProtKB/TrEMBL

Q6NXW0

Conserved Domains (2) summary

cd05593
Location:71 → 418

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

cl17171
Location:1 → 49

PH-like; Pleckstrin homology-like domain
XM_030253910.1 → XP_030109770.1 RAC-gamma serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q9WUA6

UniProtKB/TrEMBL

Q6NXW0

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_036164633.1 → XP_036020526.1 RAC-gamma serine/threonine-protein kinase isoform X7

Conserved Domains (1) summary

cl21453
Location:46 → 292

PKc_like; Protein Kinases, catalytic domain
XM_006496819.5 → XP_006496882.1 RAC-gamma serine/threonine-protein kinase isoform X1

See identical proteins and their annotated locations for XP_006496882.1

UniProtKB/Swiss-Prot

Q9WUA6

UniProtKB/TrEMBL

Q6NXW0

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_011238805.4 → XP_011237107.1 RAC-gamma serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

Q6NXW0

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:152 → 417

PKc_like; Protein Kinases, catalytic domain