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    Or8k53 olfactory receptor family 8 subfamily K member 53 [ Mus musculus (house mouse) ]

    Gene ID: 259023, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Or8k53provided by MGI
    Official Full Name
    olfactory receptor family 8 subfamily K member 53provided by MGI
    Primary source
    MGI:MGI:3030889
    See related
    Ensembl:ENSMUSG00000075189 AllianceGenome:MGI:3030889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOR186-1; Olfr1055
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Or8k53 in Genome Data Viewer
    Location:
    2 D; 2 49.78 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (86177068..86178108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (86346724..86347764, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynamin 1-like pseudogene Neighboring gene olfactory receptor family 8 subfamily K member 22 Neighboring gene STARR-seq mESC enhancer starr_05025 Neighboring gene olfactory receptor family 8 subfamily K member 23 Neighboring gene STARR-seq mESC enhancer starr_05026 Neighboring gene olfactory receptor family 8 subfamily J member 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    2. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    3. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article
    4. A unified nomenclature for vertebrate olfactory receptors. Olender T, et al. BMC Evol Biol, 2020 Apr 15. PMID 32295537, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor 1055
    Names
    GA_x6K02T2Q125-47819205-47818258
    olfactory receptor MOR186-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310551.1 → NP_001297480.1  olfactory receptor 1055 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the reference strain (C57BL/6) allele and encodes the longer isoform (a).
      Source sequence(s)
      AL935138
      Consensus CDS
      CCDS84544.1
      UniProtKB/TrEMBL
      A0A087WS05, A2AVX9
      Related
      ENSMUSP00000140847.2, ENSMUST00000188023.2
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 303
      7tm_4; Olfactory receptor

    2. NM_147021.1 → NP_667232.1  olfactory receptor 1055 isoform b

      See identical proteins and their annotated locations for NP_667232.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents a non-reference strain allele and contains a polymorphism that results in an earlier stop codon, compared to variant 1. The encoded isoform (b) is shorter at the C-terminus, compared to isoform a.
      Source sequence(s)
      AY073067
      UniProtKB/TrEMBL
      A0A087WS05, Q8VGS9
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 303
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      86177068..86178108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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