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    Nxt2 nuclear transport factor 2-like export factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 237082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nxt2provided by MGI
    Official Full Name
    nuclear transport factor 2-like export factor 2provided by MGI
    Primary source
    MGI:MGI:2147914
    See related
    Ensembl:ENSMUSG00000042271 AllianceGenome:MGI:2147914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P15-2; 6330587F24Rik
    Summary
    Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in nucleus and perinuclear region of cytoplasm. Orthologous to human NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 8.0), bladder adult (RPKM 4.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nxt2 in Genome Data Viewer
    Location:
    X F2; X 63.02 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141009766..141022696)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142226770..142239700)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2f Neighboring gene STARR-seq mESC enhancer starr_48017 Neighboring gene STARR-positive B cell enhancer mm9_chrX:138662261-138662562 Neighboring gene retinoblastoma binding protein 7 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents. Hu J, et al. Zoology (Jena), 2022 Apr. PMID 35219094
    2. The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. Lai D, et al. RNA, 2006 Aug. PMID 16790844, Free PMC Article
    3. The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice. Khan M, et al. Sci Rep, 2018 Mar 21. PMID 29563520, Free PMC Article
    4. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki M, et al. Genomics, 2005 May. PMID 15820316
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
      Title: Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear RNA export factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear RNA export factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NTF2-related export protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161430.2 → NP_001154902.1  NTF2-related export protein 2 isoform a

      See identical proteins and their annotated locations for NP_001154902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BB038253, BB857403, BC068166
      Consensus CDS
      CCDS41155.1
      UniProtKB/Swiss-Prot
      B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
      Related
      ENSMUSP00000048221.6, ENSMUST00000042329.12
      Conserved Domains (1) summary
      cd00780
      Location:13 → 138
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_001290532.1 → NP_001277461.1  NTF2-related export protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.
      Source sequence(s)
      BB038253, BC068166, CJ148018
      Consensus CDS
      CCDS72440.1
      UniProtKB/TrEMBL
      Q6P250
      Related
      ENSMUSP00000108538.3, ENSMUST00000112916.9
      Conserved Domains (1) summary
      cd00780
      Location:69 → 194
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    3. NM_001290533.1 → NP_001277462.1  NTF2-related export protein 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AL731672, BB038253, BC068166
      Consensus CDS
      CCDS72441.1
      UniProtKB/Swiss-Prot
      Q3UNA4
      Related
      ENSMUSP00000108535.2, ENSMUST00000112913.2
      Conserved Domains (1) summary
      cd00780
      Location:1 → 110
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    4. NM_172782.4 → NP_766370.2  NTF2-related export protein 2 isoform a

      See identical proteins and their annotated locations for NP_766370.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BB038253, BB851047, BC068166
      Consensus CDS
      CCDS41155.1
      UniProtKB/Swiss-Prot
      B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
      Related
      ENSMUSP00000108536.2, ENSMUST00000112914.8
      Conserved Domains (1) summary
      cd00780
      Location:13 → 138
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      141009766..141022696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251330.2 → XP_030107190.1  NTF2-related export protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
      Conserved Domains (1) summary
      cd00780
      Location:13 → 138
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. XM_030251331.2 → XP_030107191.1  NTF2-related export protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
      Conserved Domains (1) summary
      cd00780
      Location:13 → 138
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UNA4.1 GenPept UniProtKB/Swiss-Prot:Q3UNA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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