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    Gstp3 glutathione S-transferase pi 3 [ Mus musculus (house mouse) ]

    Gene ID: 225884, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gstp3provided by MGI
    Official Full Name
    glutathione S-transferase pi 3provided by MGI
    Primary source
    MGI:MGI:2385078
    See related
    Ensembl:ENSMUSG00000058216 AllianceGenome:MGI:2385078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cytokine production; and negative regulation of signal transduction. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 88.7), liver E14.5 (RPKM 32.9) and 5 other tissues See more
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    Genomic context

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    See Gstp3 in Genome Data Viewer
    Location:
    19 A; 19 3.77 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4107470..4109587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4057470..4059605, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, pi 1 Neighboring gene glutathione S-transferase, pi 2 Neighboring gene STARR-seq mESC enhancer starr_45337 Neighboring gene STARR-positive B cell enhancer ABC_E5673 Neighboring gene predicted gene, 42060 Neighboring gene small nucleolar RNA, C/D box 3B, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex. Liu X, et al. Hum Mol Genet, 2021 Mar 25. PMID 33437989, Free PMC Article
    2. Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia. Cerrato V, et al. Glia, 2018 Sep. PMID 29732603
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
      Title: Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC37914

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-nitrosoglutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dinitrosyl-iron complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione derivative biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAF2-GSTP1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase P-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362043.2 → NP_001348972.1  glutathione S-transferase P-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109138
      UniProtKB/TrEMBL
      F6RWR5
      Conserved Domains (2) summary
      cl00388
      Location:1 → 59
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:67 → 186
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001426156.1 → NP_001413085.1  glutathione S-transferase P-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109138
      UniProtKB/TrEMBL
      F6RWR5

    3. NM_144869.4 → NP_659118.1  glutathione S-transferase P-like isoform 1

      See identical proteins and their annotated locations for NP_659118.1

      Status: VALIDATED

      Source sequence(s)
      AC109138
      Consensus CDS
      CCDS79668.1
      UniProtKB/TrEMBL
      F6RWR5, Q8VC73
      Related
      ENSMUSP00000140159.2, ENSMUST00000189808.7
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 194
      PTZ00057; glutathione s-transferase; Provisional
      cd03076
      Location:3 → 76
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:84 → 203
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4107470..4109587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531725.4 → XP_006531788.1  glutathione S-transferase P-like isoform X3

      See identical proteins and their annotated locations for XP_006531788.1

      UniProtKB/TrEMBL
      F6RWR5
      Conserved Domains (2) summary
      cl00388
      Location:1 → 59
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:67 → 186
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_011248620.3 → XP_011246922.1  glutathione S-transferase P-like isoform X2

      See identical proteins and their annotated locations for XP_011246922.1

      UniProtKB/TrEMBL
      F6RWR5
      Conserved Domains (2) summary
      cd03076
      Location:3 → 94
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:102 → 221
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. XM_030250874.1 → XP_030106734.1  glutathione S-transferase P-like isoform X3

      UniProtKB/TrEMBL
      F6RWR5
      Conserved Domains (2) summary
      cl00388
      Location:1 → 59
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:67 → 186
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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