Gpt glutamic pyruvic transaminase, soluble [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gptprovided by MGI
Official Full Name: glutamic pyruvic transaminase, solubleprovided by MGI
Primary source: MGI:MGI:95802
See related: Ensembl:ENSMUSG00000022546 AllianceGenome:MGI:95802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALT; ALT1; Gpt1; Gpt-1; 1300007J06Rik; 2310022B03Rik
Summary: Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in positive regulation of gluconeogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 148.9), duodenum adult (RPKM 136.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76580926..76583875)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76696726..76699675)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We used the peripheral blood micronucleus assay to evaluate the chromosomal damage, and Pig-a gene mutation assay and gpt gene mutation assay to examine the mutagenicity of BDE-47.
Title: Gene mutation and micronucleus assays in gpt delta mice treated with 2,2',4,4'-tetrabromodiphenyl ether.
Dexamethasone induces a metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice.
Title: Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone.
PKCdelta activation and protein levels are elevated in an animal model of steatohepatitis, which was recapitulated in a cell model, supporting the conclusion that PKCdelta plays a role in ALT release, the ER stress signal, and cell death
Title: PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death.
In experiments where mice were provided ethanol chronically in drinking water, where stress is minimal, higher levels of ALT were noted in animals in the ethanol group as compared with animals in the control group.
Title: Rescue of in vivo FAS-induced apoptosis of hepatocytes by corticosteroids either associated with alcohol consumption by mice or provided exogenously.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alanine aminotransferase 1

Names: GPT 1; glutamate pyruvate transaminase 1; glutamic pyruvic transaminase 1, soluble; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1

NP_877957.1

EC 2.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182805.3 → NP_877957.1 alanine aminotransferase 1

See identical proteins and their annotated locations for NP_877957.1

Status: VALIDATED

Source sequence(s)

AC156550, AI196515, AK009457, BU706045

Consensus CDS

CCDS27586.1

UniProtKB/Swiss-Prot

Q8QZR5

UniProtKB/TrEMBL

Q566C3

Related

ENSMUSP00000023203.5, ENSMUST00000023203.6

Conserved Domains (2) summary

cd00609
Location:98 → 485

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PTZ00377
Location:19 → 496

PTZ00377; alanine aminotransferase; Provisional