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    Ccdc116 coiled-coil domain containing 116 [ Mus musculus (house mouse) ]

    Gene ID: 76872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc116provided by MGI
    Official Full Name
    coiled-coil domain containing 116provided by MGI
    Primary source
    MGI:MGI:1924122
    See related
    Ensembl:ENSMUSG00000022768 AllianceGenome:MGI:1924122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930432J16Rik
    Summary
    Predicted to be located in cytoplasm. Predicted to be active in centrosome. Is expressed in ductus deferens; epididymis; ileum; and testis. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CCDC116 (coiled-coil domain containing 116). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 40.8), duodenum adult (RPKM 4.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc116 in Genome Data Viewer
    Location:
    16 A3; 16 10.62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16956928..16965459, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17139064..17147802, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E214 Neighboring gene stromal cell-derived factor 2-like 1 Neighboring gene Rps20 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
    2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 116

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306169.1 → NP_001293098.1  coiled-coil domain-containing protein 116 isoform 1

      See identical proteins and their annotated locations for NP_001293098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      BC050881, BC057359
      Consensus CDS
      CCDS27995.1
      UniProtKB/Swiss-Prot
      Q6PFY7, Q80X53, Q9D5J4
      Related
      ENSMUSP00000023452.8, ENSMUST00000023452.16
      Conserved Domains (1) summary
      pfam15774
      Location:24 → 408
      DUF4702; Domain of unknown function (DUF4702)

    2. NM_001373948.1 → NP_001360877.1  coiled-coil domain-containing protein 116 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Consensus CDS
      CCDS88887.1
      UniProtKB/TrEMBL
      A0A338P7I8
      Related
      ENSMUSP00000156301.2, ENSMUST00000232540.2
      Conserved Domains (1) summary
      pfam15774
      Location:18 → 408
      DUF4702; Domain of unknown function (DUF4702)

    3. NM_029779.2 → NP_084055.2  coiled-coil domain-containing protein 116 isoform 1

      See identical proteins and their annotated locations for NP_084055.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK015290, BC057359
      Consensus CDS
      CCDS27995.1
      UniProtKB/Swiss-Prot
      Q6PFY7, Q80X53, Q9D5J4
      Related
      ENSMUSP00000155923.2, ENSMUST00000232033.2
      Conserved Domains (1) summary
      pfam15774
      Location:24 → 408
      DUF4702; Domain of unknown function (DUF4702)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16956928..16965459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317158.3 → XP_017172647.1  coiled-coil domain-containing protein 116 isoform X2

      UniProtKB/Swiss-Prot
      Q6PFY7, Q80X53, Q9D5J4
      Conserved Domains (1) summary
      pfam15774
      Location:24 → 408
      DUF4702; Domain of unknown function (DUF4702)

    2. XM_006522710.2 → XP_006522773.1  coiled-coil domain-containing protein 116 isoform X1

      See identical proteins and their annotated locations for XP_006522773.1

      UniProtKB/TrEMBL
      A0A338P7I8
      Conserved Domains (1) summary
      pfam15774
      Location:18 → 408
      DUF4702; Domain of unknown function (DUF4702)

    3. XM_006522709.5 → XP_006522772.1  coiled-coil domain-containing protein 116 isoform X1

      See identical proteins and their annotated locations for XP_006522772.1

      UniProtKB/TrEMBL
      A0A338P7I8
      Conserved Domains (1) summary
      pfam15774
      Location:18 → 408
      DUF4702; Domain of unknown function (DUF4702)

    4. XM_036160177.1 → XP_036016070.1  coiled-coil domain-containing protein 116 isoform X1

      UniProtKB/TrEMBL
      A0A338P7I8
      Conserved Domains (1) summary
      pfam15774
      Location:18 → 408
      DUF4702; Domain of unknown function (DUF4702)

    5. XM_006522708.5 → XP_006522771.1  coiled-coil domain-containing protein 116 isoform X1

      See identical proteins and their annotated locations for XP_006522771.1

      UniProtKB/TrEMBL
      A0A338P7I8
      Conserved Domains (1) summary
      pfam15774
      Location:18 → 408
      DUF4702; Domain of unknown function (DUF4702)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001164606.1: Suppressed sequence

      Description
      NM_001164606.1: This RefSeq was permanently suppressed because there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X53.1 GenPept UniProtKB/Swiss-Prot:Q80X53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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