Ggct gamma-glutamyl cyclotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ggctprovided by MGI
Official Full Name: gamma-glutamyl cyclotransferaseprovided by MGI
Primary source: MGI:MGI:95700
See related: Ensembl:ENSMUSG00000002797 AllianceGenome:MGI:95700
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ggc; Gctg; A030007L17Rik
Summary: Predicted to enable gamma-glutamylcyclotransferase activity and protein homodimerization activity. Predicted to be involved in release of cytochrome c from mitochondria. Predicted to be located in cytosol. Is expressed in lens. Orthologous to human GGCT (gamma-glutamylcyclotransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 3.0), frontal lobe adult (RPKM 2.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.26 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (54962080..54969947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (54985095..54992960, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by gamma-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.
Title: Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.
Ggct (gamma-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival.
Title: Ggct (γ-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-glutamylcyclotransferase activity	ISO Inferred from Sequence Orthology more info
enables gamma-glutamylcyclotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gamma-glutamylcyclotransferase

NP_080913.1

EC 4.3.2.9

XP_006505429.1

EC 4.3.2.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026637.3 → NP_080913.1 gamma-glutamylcyclotransferase

See identical proteins and their annotated locations for NP_080913.1

Status: PROVISIONAL

Source sequence(s)

AK079465

Consensus CDS

CCDS20161.1

UniProtKB/Swiss-Prot

Q3URJ2, Q66JQ5, Q9D7X8

Related

ENSMUSP00000120154.2, ENSMUST00000131475.2

Conserved Domains (1) summary

pfam13772
Location:78 → 160

AIG2_2; AIG2-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

54962080..54969947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505366.5 → XP_006505429.1 gamma-glutamylcyclotransferase isoform X1

Conserved Domains (1) summary

cd06661
Location:19 → 97

GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...