Mup4 major urinary protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mup4provided by MGI
Official Full Name: major urinary protein 4provided by MGI
Primary source: MGI:MGI:97236
See related: Ensembl:ENSMUSG00000041333 AllianceGenome:MGI:97236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mup1; Mup-4
Summary: Predicted to enable insulin receptor activity and pheromone binding activity. Predicted to be involved in several processes, including locomotor rhythm; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Located in extracellular space. Is expressed in dermis and tail. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 2.5) See more
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Genomic context

Location:: 4 B3; 4 32.82 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (59956804..59960667, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (59956804..59960667, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data determine the X-ray crystal structure of major urinary protein-IV bound to three mouse pheromones: SBT, 2,5-dimethylpyrazine, and 2-heptanone, and report the structure of MUP-IV with 2-ethylhexanol bound in the cavity.
Title: High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables pheromone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipid	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy reserve metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heat generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: major urinary protein 4

Names: MUP 4; major urinary protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008648.2 → NP_032674.1 major urinary protein 4 precursor

See identical proteins and their annotated locations for NP_032674.1

Status: VALIDATED

Source sequence(s)

AL831738

Consensus CDS

CCDS18228.1

UniProtKB/Swiss-Prot

P11590

UniProtKB/TrEMBL

A2ANT5

Related

ENSMUSP00000075356.3, ENSMUST00000075973.3

Conserved Domains (1) summary

pfam00061
Location:32 → 171

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family