Pp2d1 protein phosphatase 2C-like domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pp2d1provided by MGI
Official Full Name: protein phosphatase 2C-like domain containing 1provided by MGI
Primary source: MGI:MGI:3612067
See related: Ensembl:ENSMUSG00000044957 AllianceGenome:MGI:3612067
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4921523A10Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human PP2D1 (protein phosphatase 2C like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 8.6), cortex adult (RPKM 1.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 27.83 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (53814488..53846479, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (53507460..53539451, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

General gene information

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Markers

D17Mit274 (e-PCR), detects polymorphism
- UniSTS:128078

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 2C-like domain-containing protein 1

Names: PP2C-like domain-containing protein C3orf48 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173449.3 → NP_775625.1 protein phosphatase 2C-like domain-containing protein 1

See identical proteins and their annotated locations for NP_775625.1

Status: PROVISIONAL

Source sequence(s)

AC131785, AC165960

Consensus CDS

CCDS37653.1

UniProtKB/Swiss-Prot

Q8BVT6

Related

ENSMUSP00000056682.4, ENSMUST00000056198.4

Conserved Domains (1) summary

cd00143
Location:187 → 472

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...